Document Detail


Lipids of three microsporidian species and multivariate analysis of the host-parasite relationship.
MedLine Citation:
PMID:  11426718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sporal lipids of 3 microsporidia, Encephalitozoon cuniculi from mammals and Glugea atherinae and Spraguea lophii from fishes, were investigated. High phospholipid levels were found (54.8-64.5% of total lipids), which is in agreement with the presence of highly developed internal membranes in microsporidian spores. Sphingomyelin was not detected in G. atherinae. Triglycerides (less than 10% of total lipids), cholesterol, and free fatty acids were identified in all species. Analysis of fatty acids from the phospholipid fraction revealed the predominance of docosahexaenoic acid (30-40% of total phospholipid fatty acids) in G. atherinae and S. lophii and oleic acid (25.8% of total phospholipid fatty acids) in E. cuniculi. The 3 microsporidia possessed a significant amount of branched-chain fatty acids (iso and anteiso forms) not found in the hosts, supporting the existence of some parasite-specific metabolic steps for these fatty acids. On the basis of phospholipid fatty acid profiles, host-parasite relationships were investigated through correspondence factorial analysis. It shows 3 distinct clusters with the first corresponding to fishes, the second to fish parasites, and the third to E. cuniculi and its host cell. These data suggest that the mammal microsporidia developing within parasitophorous vacuoles are more dependent on host cells than the fish microsporidia that induce cystlike structures.
Authors:
H El Alaoui; J Bata; D Bauchart; J C Doré; C P Vivarès
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of parasitology     Volume:  87     ISSN:  0022-3395     ISO Abbreviation:  J. Parasitol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-27     Completed Date:  2001-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7803124     Medline TA:  J Parasitol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  554-9     Citation Subset:  IM    
Affiliation:
Laboratoire de Parasitologie Moléculaire et Cellulaire, LBP, UMR CNRS 6023, Université Blaise Pascal, Aubière, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cluster Analysis
Encephalitozoon cuniculi / chemistry*
Factor Analysis, Statistical
Fatty Acids / analysis
Fishes
Host-Parasite Interactions
Humans
Lipids / analysis*
Mice
Microsporidia / chemistry*
Phospholipids / analysis,  chemistry
Spores / chemistry
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Lipids; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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