Document Detail

Lipids and lysosomes.
MedLine Citation:
PMID:  22978393     Owner:  NLM     Status:  Publisher    
Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis, phagocytosis or autophagy. In this review, we describe the lipid composition and the dynamic properties of lysosomal membrane, the main delivery pathways of lipids to lysosomes and their catabolism inside lysosomes. Then, we present the consequences of a lipid accumulation as seen in various lysosomal storage diseases on lysosomal functions. Finally, we discuss about the possible involvement of lysosomes in lipotoxicity.
Isabelle Hamer; Guillaume Van Beersel; Thierry Arnould; Michel Jadot
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-04
Journal Detail:
Title:  Current drug metabolism     Volume:  -     ISSN:  1875-5453     ISO Abbreviation:  Curr. Drug Metab.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960533     Medline TA:  Curr Drug Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
NARILIS, NAmur Research Institute for Life Sciences, University of Namur (FUNDP), Rue de Bruxelles, 61, B-5000 Namur, Belgium.
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