| Lipids and lysosomes. | |
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MedLine Citation:
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PMID: 22978393 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lysosomes are cytoplasmic organelles delimited by a single membrane and filled with a variety of hydrolytic enzymes active at acidic pH and collectively capable to degrade the vast majority of macromolecules entering lysosomes via endocytosis, phagocytosis or autophagy. In this review, we describe the lipid composition and the dynamic properties of lysosomal membrane, the main delivery pathways of lipids to lysosomes and their catabolism inside lysosomes. Then, we present the consequences of a lipid accumulation as seen in various lysosomal storage diseases on lysosomal functions. Finally, we discuss about the possible involvement of lysosomes in lipotoxicity. |
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Authors:
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Isabelle Hamer; Guillaume Van Beersel; Thierry Arnould; Michel Jadot |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-04 |
Journal Detail:
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Title: Current drug metabolism Volume: - ISSN: 1875-5453 ISO Abbreviation: Curr. Drug Metab. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960533 Medline TA: Curr Drug Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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NARILIS, NAmur Research Institute for Life Sciences, University of Namur (FUNDP), Rue de Bruxelles, 61, B-5000 Namur, Belgium. isabelle.hamer@fundp.ac.be. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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