Document Detail

Lipids as modulators of bone remodelling.
MedLine Citation:
PMID:  11224653     Owner:  NLM     Status:  MEDLINE    
Bone remodelling processes are regulated by systemic hormones and a multitude of local and systemic factors, including prostaglandins, cytokines, and growth factors. Dietary fatty acids and their derivatives (eicosanoids) have been a recent focus of investigation on bone and cartilage metabolism. Specific fatty acids are recognized modulators of eicosanoid biosynthesis, signal transduction, and gene expression. The actions of polyunsaturated fatty acids have not been extensively examined in the skeletal system. Promising research on fatty acids and bone remodelling should evaluate the potential effects on pathways for osteoclastogenesis and osteoblastogenesis.
B A Watkins; Y Li; M F Seifert
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  4     ISSN:  1363-1950     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-07-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
Department of Food Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, Indiana 47907, USA.
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MeSH Terms
Bone Remodeling*
Bone and Bones / metabolism*
Dietary Fats
Fatty Acids, Unsaturated / administration & dosage*,  metabolism
Lipid Metabolism*
Osteoporosis / prevention & control
Risk Factors
Signal Transduction
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Unsaturated

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