Document Detail


Lipids of 'Mycobacterium habana', a synonym of Mycobacterium simiae with vaccine potential.
MedLine Citation:
PMID:  16632407     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
'Mycobacterium habana' was proposed as a distinct species within the genus Mycobacterium; however, it is actually a synonym of Mycobacterium simiae and included in the serotype I of this species. The potential use of 'M. habana' as a vaccine in both leprosy and tuberculosis has led to the analysis of its lipid composition in an attempt to define distinctive markers that could be used in the quality control of true strains of this bacterium. Lipids of taxonomic value (fatty and mycolic acids) are similar in 'M. habana' and M. simiae; nevertheless, they clearly differ on the basis of glycopeptidolipid (GPL) composition. Thus, contrary to M. simiae, most strains of 'M. habana' can be defined by the presence of three polar compounds, designated GPL-I, GPL-II and GPL-III, easily determined by thin-layer chromatography, and characterized, respectively, by the content of l-fucose, 2,4-di-O-Me-d-glucuronic acid, and 4-O-Me-d-glucuronic acid, as epitopes.
Authors:
L M Mederos; J A Valdivia; P L Valero-Guillén
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-04-24
Journal Detail:
Title:  Tuberculosis (Edinburgh, Scotland)     Volume:  86     ISSN:  1472-9792     ISO Abbreviation:  Tuberculosis (Edinb)     Publication Date:    2006 May-Jul
Date Detail:
Created Date:  2006-05-08     Completed Date:  2007-04-05     Revised Date:  2009-04-22    
Medline Journal Info:
Nlm Unique ID:  100971555     Medline TA:  Tuberculosis (Edinb)     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  324-9     Citation Subset:  IM    
Affiliation:
Laboratorio Nacional de Referencias e Investigaciones de Tuberculosis y Micobacterias, Centro Colaborador OMS/OPS, Instituto de Medicina Tropical Pedro Kourí (IPK), La Habana, Cuba.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Typing Techniques / methods
Bacterial Vaccines / chemistry
Chromatography, Thin Layer
Fatty Acids / analysis
Glycolipids / analysis
Humans
Leprosy / prevention & control
Lipids / analysis*
Mice
Mycobacteria, Atypical / chemistry*,  classification,  immunology
Mycolic Acids / analysis
Tuberculosis Vaccines / chemistry
Chemical
Reg. No./Substance:
0/Bacterial Vaccines; 0/Fatty Acids; 0/Glycolipids; 0/Lipids; 0/Mycolic Acids; 0/Tuberculosis Vaccines

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