| Lipidomics of polyunsaturated-fatty-acid-derived oxygenated metabolites. | |
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MedLine Citation:
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PMID: 21936796 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Nutritionally important PUFAs (polyunsaturated fatty acids) mediate some of their bioactivities through formation of oxygenated metabolites. These bioactive lipids are formed by COX (cyclo-oxygenase), LOX (lipoxygenase) and cytochrome-P450-catalysed reactions, as well as non-enzymatic lipid peroxidation. These reactions produce numerous species, some of which can be formed through more than one pathway. MS-based lipidomics offers the selectivity and sensitivity required for qualitative and quantitative analysis of multiple lipid species, in a variety of biological systems, and can facilitate the study of these mediators. |
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Authors:
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Karen A Massey; Anna Nicolaou |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical Society transactions Volume: 39 ISSN: 1470-8752 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 1240-6 Citation Subset: IM |
Affiliation:
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Bradford School of Pharmacy and Centre for Skin Sciences, School of Life Sciences, University of Bradford, Bradford BD7 1DP, U.K. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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