| Lipid triad or atherogenic lipoprotein phenotype: a role in cardiovascular prevention? | |
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MedLine Citation:
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PMID: 16205019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The term "lipid triad" or "atherogenic lipoprotein phenotype" has been introduced to describe a common form of dyslipidemia, characterized by three lipid abnormalities: increased plasma triglyceride levels, decreased HDL-cholesterol concentrations and the presence of small, dense LDL particles. It has been suggested that the clinical importance of the atherogenic lipoprotein phenotype probably exceeds that of LDL-cholesterol, because many more patients with coronary artery disease are found to have this trait than hypercholesterolaemia. There is a body of evidence that therapies effective against plasma HDL-cholesterol and triglycerides are associated with a strong reduction of cardiovascular risk; in addition, hypolipidemic treatment is able to increase LDL particle size and this increment correlates with regression of coronary stenosis. Recently, the Coordinating Committee of the National Cholesterol Education Program suggested that very high-risk patients may benefit from stronger lipid-lowering measures, a category of individuals that includes those with the atherogenic lipoprotein phenotype. Since the therapeutical modulation of each of the three components of the lipid triad is associated with a strong reduction in the risk of cardiovascular events, LDL size measurement may be extended as much as possible to patients at high risk of cardiovascular diseases. |
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Authors:
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Manfredi Rizzo; Kaspar Berneis |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 12 ISSN: 1340-3478 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-10-05 Completed Date: 2006-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 237-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine and Emerging Diseases, University of Palermo, Via del Vespro 141, Palermo 90127, Italy. mrizzo@unipa.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antilipemic Agents
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therapeutic use Atherosclerosis / blood* Cardiovascular Diseases / blood, prevention & control Dyslipidemias / blood, complications*, drug therapy Humans Lipoproteins, LDL / blood*, classification |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Lipoproteins, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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