| Lipid treatment assessment project 2: a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals. | |
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MedLine Citation:
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PMID: 19546386 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Information about physicians' adherence to cholesterol management guidelines remains scant. The present survey updates our knowledge of lipid management worldwide. METHODS AND RESULTS: Lipid levels were determined at enrollment in dyslipidemic adult patients on stable lipid-lowering therapy in 9 countries. The primary end point was the success rate, defined as the proportion of patients achieving appropriate low-density lipoprotein cholesterol (LDL-C) goals for their given risk. The mean age of the 9955 evaluable patients was 62+/-12 years; 54% were male. Coronary disease and diabetes mellitus had been diagnosed in 30% and 31%, respectively, and 14% were current smokers. Current treatment consisted of a statin in 75%. The proportion of patients achieving LDL-C goals according to relevant national guidelines ranged from 47% to 84% across countries. In low-, moderate-, and high-risk groups, mean LDL-C was 119, 109, and 91 mg/dL and mean high-density lipoprotein cholesterol was 62, 49, and 50 mg/dL, respectively. The success rate for LDL-C goal achievement was 86% in low-, 74% in moderate-, and 67% in high-risk patients (73% overall). However, among coronary heart disease patients with > or =2 risk factors, only 30% attained the optional LDL-C goal of <70 mg/dL. In the entire cohort, high-density lipoprotein cholesterol was <40 mg/dL in 19%, 40 to 60 mg/dL in 55%, and >60 mg/dL in 26% of patients. CONCLUSIONS: Although there is room for improvement, particularly in very-high-risk patients, these results indicate that lipid-lowering therapy is being applied much more successfully than it was a decade ago. |
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Authors:
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David D Waters; Carlos Brotons; Cheng-Wen Chiang; Jean Ferri?res; JoAnne Foody; J Wouter Jukema; Raul D Santos; Juan Verdejo; Michael Messig; Ruth McPherson; Ki-Bae Seung; Lisa Tarasenko; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-22 |
Journal Detail:
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Title: Circulation Volume: 120 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-07 Completed Date: 2009-07-30 Revised Date: 2010-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 28-34 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, San Francisco General Hospital and University of California, San Francisco, CA 94114, USA. dwaters@medsfgh.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antilipemic Agents / therapeutic use* Cholesterol, HDL / blood Cholesterol, LDL / blood* Coronary Disease / epidemiology* Diabetes Mellitus / epidemiology Female Guideline Adherence Health Care Surveys Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hypercholesterolemia / blood, drug therapy*, epidemiology* Male Middle Aged Risk Factors Smoking / epidemiology World Health |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
| Comments/Corrections | |
Comment In:
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Circulation. 2010 Mar 9;121(9):e233
[PMID:
20212288
]
Circulation. 2009 Jul 7;120(1):3-5 [PMID: 19546383 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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