Document Detail

Lipid transport, dietary fats, and endogenous lipid synthesis: hypotheses on saturation and competition processes.
MedLine Citation:
PMID:  16859175     Owner:  NLM     Status:  MEDLINE    
Plasma lipid concentrations are the net result of the balance between two opposite processes: the loading, i.e. the entry of new lipids into the plasma compartment through the ingestion (diet) and/or endogenous synthesis, and the unloading, i.e. energy utilization, incorporation into cell membranes, and storage. Even though many fatty acids are thought to be synthesized in the body, it appears as nearly all circulating fatty acids are, in fact, derived from the diet. In view of the wide dietary availabilty of such nutrients, the need to conserve energy likely minimizes endogenous synthesis. Consequently, the possibility exists to alter circulating the profile of fatty acids, including the "non essential" ones by dietary manipulations. In turn, a theory on the dietary vs endogenous contribution to circulating fatty acids, including those known as non-essential, is discussed based on critical interpretation of original data.
Francesco Visioli; Michael A Crawford; Stephen Cunnane; Patrizia Rise; Claudio Galli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition and health     Volume:  18     ISSN:  0260-1060     ISO Abbreviation:  Nutr Health     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-09-07     Revised Date:  2012-02-23    
Medline Journal Info:
Nlm Unique ID:  8306569     Medline TA:  Nutr Health     Country:  England    
Other Details:
Languages:  eng     Pagination:  127-32     Citation Subset:  IM    
University of Milan, Department of Pharmacological Sciences, Italy,
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MeSH Terms
Blood Chemical Analysis
Chromatography, Gas / methods
Dietary Fats / administration & dosage*,  metabolism
Energy Metabolism / physiology*
Fatty Acids / analysis*,  chemistry
Lipid Metabolism / drug effects,  physiology*
Lipogenesis / drug effects,  physiology*
Lipolysis / drug effects,  physiology*
Middle Aged
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids

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