Document Detail


Lipid therapy with two agents in ropivacaine-induced toxicity: experimental study in Swine.
MedLine Citation:
PMID:  22999401     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Compare hemodynamic changes after ropivacaine-induced toxicity followed by treatment with two lipid emulsions in swine.
METHODS: Large White pigs were anesthetized with thiopental, followed by intubation, and kept on mechanical ventilation. Hemodynamic variables at rest were recorded with invasive pressure monitoring and pulmonary artery catheterization. After 30 minutes, 7mg.kg(-1) ropivacaine were injected intravenously and new hemodynamic measurements were performed within one minute. The animals were then randomly allocated into three groups and received: 4mL.kg(-1) saline solution, or 4mL.kg(-1) lipid emulsion with long-chain triglycerides, or 4mL.kg(-1) lipid emulsion with longand medium-chain triglycerides. Hemodynamic changes were reevaluated at 5, 10, 15, 20 and 30 minutes.
RESULTS: Ropivacaine-induced toxicity mainly caused a drop in blood pressure and cardiac index without significant changes in vascular resistance. Therapy with lipid emulsions restored blood pressure primarily through increased vascular resistance, as cardiac index showed no significant improvement. Lipid emulsion with medium-chain triglycerides caused a greater increase in vascular resistance, particularly pulmonary.
CONCLUSION: In groups receiving lipid emulsions, hemodynamic results were better than in control group. There were no differences in systemic arterial pressure and cardiac index between animals receiving lipid emulsion with long-chain triglycerides and mixed long- and medium-chain triglycerides.
Authors:
Matheus Rodrigues Bonfim; Marcos De Simone Melo; Elisabeth Dreyer; Luís Fernando Affini Borsoi; Thales Gê de Oliveira; Artur Udelsmann
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista brasileira de anestesiologia     Volume:  62     ISSN:  1806-907X     ISO Abbreviation:  Rev Bras Anestesiol     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-09-24     Completed Date:  2013-11-22     Revised Date:  2014-02-05    
Medline Journal Info:
Nlm Unique ID:  0401316     Medline TA:  Rev Bras Anestesiol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  685-95     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Editora Ltda. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Amides / adverse effects*
Anesthetics, Local / adverse effects*
Animals
Drug-Related Side Effects and Adverse Reactions / drug therapy
Fat Emulsions, Intravenous / therapeutic use*
Swine
Triglycerides / therapeutic use*
Chemical
Reg. No./Substance:
0/Amides; 0/Anesthetics, Local; 0/Fat Emulsions, Intravenous; 0/Triglycerides; 7IO5LYA57N/ropivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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