| Lipid status, paraoxonase-1 activity and metabolic parameters in serum of heifers and lactating cows related to oxidative stress. | |
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MedLine Citation:
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PMID: 20579677 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The objective of this study was to investigate serum lipids, metabolic parameters and activity of the anti-oxidative enzyme paraoxonase-1 (PON1). The study was conducted on non-pregnant heifers with optimal health status and on healthy dairy cows in the period of intensive lactation, assuming that the energy and metabolic demands during lactation reduce anti-oxidative protection. Total cholesterol and HDL-cholesterol concentrations were significantly higher (P<0.05) in lactating cows than in heifers. Bilirubin concentration and γ-glutamyltransferase (GGT) activity were also significantly higher in lactating cows (P<0.05), indicating increased hepatic efforts of cows to meet energy requirements for lactation. Significantly lower PON1 activity and PON1/HDL ratio in lactating cows compared to heifers (P<0.05) showed that metabolic efforts during pregnancy, parturition and lactation influence PON1 activity due to oxidative stress. Concurrent increase in total and HDL-cholesterol during lactation indicated that the HDL particle is a major carrier of cholesterol in cows. |
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Authors:
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M Antončić-Svetina; R Turk; A Svetina; D Gereš; B Rekić; D Juretić |
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Publication Detail:
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Type: Journal Article Date: 2010-06-25 |
Journal Detail:
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Title: Research in veterinary science Volume: 90 ISSN: 1532-2661 ISO Abbreviation: Res. Vet. Sci. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-02-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: England |
Other Details:
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Languages: eng Pagination: 298-300 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institute of Cardiovascular Prevention and Rehabilitation Zagreb, Draškovićeva 13, Zagreb, Croatia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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