| Lipid responses to a dietary docosahexaenoic acid supplement in men and women with below average levels of high density lipoprotein cholesterol. | |
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MedLine Citation:
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PMID: 15930485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess fasting lipid responses to a docosahexaenoic acid (DHA) supplement in men and women with below-average levels of high-density lipoprotein (HDL) cholesterol. METHODS: This randomized, double-blind, controlled clinical trial included 57 subjects, 21-80 years of age, with fasting HDL cholesterol concentrations < or =44 mg/dL (men) and < or =54 mg/dL (women), but > or =35 mg/dL. Subjects were randomly assigned to receive either 1.52 g/day DHA from capsules containing DHA-rich algal triglycerides or olive oil (control) for six weeks. RESULTS: There were no significant differences between groups in baseline lipid values. The DHA supplemented group showed significant changes [-43 (DHA) vs. -14 (controls) mg/dL, p = 0.015] and percent changes [-21% (DHA) vs. -7% (controls), p = 0.009] in triglycerides, total (12 vs. 3 mg/dL; p = 0.021 and 6% vs. 2%; p = 0.018) and low-density lipoprotein (17 vs. 3 mg/dL; p = 0.001 and 12% vs. 3%; p = 0.001) cholesterol concentrations, and in the triglyceride to HDL cholesterol ratio (-1.33 vs. -0.50, p = 0.010), compared with controls. In addition, there was a significant reduction in the percentage of LDL cholesterol carried by small, dense particles in the DHA supplemented group (changes = -10% vs. -3%, p = 0.025). CONCLUSIONS: Supplementation with 1.52 g/d of DHA in men and women with below-average HDL cholesterol concentrations raised the LDL cholesterol level, but had favorable effects on triglycerides, the triglyceride/HDL cholesterol ratio and the fraction of LDL cholesterol carried by small, dense particles. Further research is warranted to evaluate the net impact of these alterations on cardiovascular risk. |
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Authors:
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Kevin C Maki; Mary E Van Elswyk; Deanna McCarthy; Serena P Hess; Patricia E Veith; Marjorie Bell; Papasani Subbaiah; Michael H Davidson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Nutrition Volume: 24 ISSN: 0731-5724 ISO Abbreviation: J Am Coll Nutr Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-02 Completed Date: 2005-11-25 Revised Date: 2008-06-23 |
Medline Journal Info:
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Nlm Unique ID: 8215879 Medline TA: J Am Coll Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 189-99 Citation Subset: IM |
Affiliation:
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M.D., Radiant Development, 515 N. State St., 27th Floor, Chicago, IL 60610, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Body Weight / drug effects Cholesterol, HDL / blood* Dietary Supplements* Docosahexaenoic Acids / administration & dosage*, adverse effects, blood* Double-Blind Method Fasting / blood Fatty Acids / blood Female Humans Lipids / blood* Male Middle Aged Motor Activity / physiology Plant Oils / administration & dosage Questionnaires |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Fatty Acids; 0/Lipids; 0/Plant Oils; 25167-62-8/Docosahexaenoic Acids; 8001-25-0/olive oil |
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