| Lipid remodeling in mouse liver and plasma resulting from delta6 fatty acid desaturase inhibition. | |
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MedLine Citation:
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PMID: 11795852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Electrospray/tandem mass spectrometry was used to quantify lipid remodeling in mouse liver and plasma during inhibition of polyunsaturated fatty acid synthesis by the delta6 fatty acid desaturase inhibitor, SC-26196. SC-26196 caused increases in linoleic acid and corresponding decreases in arachidonic acid and docosahexaenoic acid in select molecular species of phosphatidylcholine, phosphatidylethanolamine, and cholesterol esters but not in phosphatidylserine, phosphatidylinositol, or triglycerides. For linoleic acid-, arachidonic acid-, and docosahexaenoic acid-containing phospholipid species, this difference was, in part, determined by the fatty acid at the sn-1 position, namely, palmitic or stearic acid. An understanding of phospholipid remodeling mediated by delta6 desaturase inhibition should aid in clarifying the contribution of arachidonic acid derived via de novo synthesis or obtained directly in the diet during inflammatory responses. |
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Authors:
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K L Duffin; M G Obukowicz; W J Salsgiver; D J Welsch; C Shieh; A Raz; P Needleman |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lipids Volume: 36 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2002-01-17 Completed Date: 2002-08-13 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: United States |
Other Details:
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Languages: eng Pagination: 1203-8 Citation Subset: IM |
Affiliation:
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Analytical Sciences, Pharmacia Corporation, St. Louis, Missouri 63198, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / metabolism Blood / drug effects, metabolism Docosahexaenoic Acids / metabolism Enzyme Inhibitors / pharmacology Fatty Acid Desaturases / antagonists & inhibitors* Female Linoleic Acid / metabolism Linoleoyl-CoA Desaturase Lipid Metabolism* Lipids / chemistry* Liver / drug effects, metabolism* Mice Mice, Inbred BALB C Piperazines / pharmacology Spectrometry, Mass, Electrospray Ionization / methods |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Lipids; 0/Piperazines; 0/SC 26196; 2197-37-7/Linoleic Acid; 25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.3/Linoleoyl-CoA Desaturase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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