| Lipid rafts: new tools and a new component. | |
| | |
MedLine Citation:
|
PMID: 16880598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Lipid rafts are liquid ordered membrane domains enriched with sphingolipids and cholesterol. After 20 years since the proposal of the original concept, the structure and function of lipid rafts are still obscure. Recently new tools to study lipid rafts have been developed. Lysenin is a sphingomyelin binding protein that specifically recognizes the lipid clusters. Poly(ethyleneglycol)-derivatized cholesterol ether (PEG-Chol) is a non-toxic cholesterol probe. These probes have revealed the heterogeneity of lipid rafts. The heterogeneity of lipid rafts is further supported by the discovery of a new lipid component, phosphatidylglucoside. Metabolic inhibitors are another useful tool. Sulfamisterin is a new addition to the serine palmitoyltransferase inhibitors. Recent findings have uncovered a previously unrecognized activity of a glycosphingolipid synthesis inhibitor, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP). |
| | |
Authors:
|
Toshihide Kobayashi; Miwa Takahashi; Yasuko Nagatsuka; Yoshio Hirabayashi |
Related Documents
:
|
17510668 - Lipid mediators in membrane rafts are important determinants of human health and disease. 17083918 - Detection of cholesterol-rich microdomains in the inner leaflet of the plasma membrane. 12736268 - Structure and dynamics of the phospholipase c-delta1 pleckstrin homology domain located... 16584138 - Detergent-resistant membrane microdomains in the disposition of the lipid signaling mol... 11822398 - Temperature-dependent refractive index issues using a uv-visible detector in high-perfo... 22241618 - Free-energy landscapes of ion movement through a g-quadruplex dna channel. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Biological & pharmaceutical bulletin Volume: 29 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-08-01 Completed Date: 2006-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
|
Languages: eng Pagination: 1526-31 Citation Subset: IM |
Affiliation:
|
Lipid Biology Laboratory, RIKEN (Institute of Physical and Chemical Research), Japan. kobayasi@riken.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Lipids
/
chemistry* Molecular Probes Sphingolipids / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Lipids; 0/Molecular Probes; 0/Sphingolipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Development of a versatile expression plasmid construction system for Aspergillus oryzae and its app...
Next Document: Insulin resistance as a membrane microdomain disorder.