Document Detail


Lipid rafts: elusive or illusive?
MedLine Citation:
PMID:  14622593     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There has been considerable recent interest in the possibility that the plasma membrane contains lipid "rafts," microdomains enriched in cholesterol and sphingolipids. It has been suggested that such rafts could play an important role in many cellular processes including signal transduction, membrane trafficking, cytoskeletal organization, and pathogen entry. However, rafts have proven difficult to visualize in living cells. Most of the evidence for their existence and function relies on indirect methods such as detergent extraction, and a number of recent studies have revealed possible problems with these methods. Direct studies of the distribution of raft components in living cells have not yet reached a consensus on the size or even the presence of these microdomains, and hence it seems that a definitive proof of raft existence has yet to be obtained.
Authors:
Sean Munro
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cell     Volume:  115     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-18     Completed Date:  2004-01-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-88     Citation Subset:  IM    
Affiliation:
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom. sean@mrc-lmb.cam.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholesterol / metabolism
Detergents / pharmacology
Glycosylphosphatidylinositols / metabolism
Humans
Membrane Lipids / metabolism
Membrane Microdomains / chemistry,  drug effects,  metabolism*
Models, Biological*
Chemical
Reg. No./Substance:
0/Detergents; 0/Glycosylphosphatidylinositols; 0/Membrane Lipids; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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