| Lipid rafts: elusive or illusive? | |
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MedLine Citation:
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PMID: 14622593 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There has been considerable recent interest in the possibility that the plasma membrane contains lipid "rafts," microdomains enriched in cholesterol and sphingolipids. It has been suggested that such rafts could play an important role in many cellular processes including signal transduction, membrane trafficking, cytoskeletal organization, and pathogen entry. However, rafts have proven difficult to visualize in living cells. Most of the evidence for their existence and function relies on indirect methods such as detergent extraction, and a number of recent studies have revealed possible problems with these methods. Direct studies of the distribution of raft components in living cells have not yet reached a consensus on the size or even the presence of these microdomains, and hence it seems that a definitive proof of raft existence has yet to be obtained. |
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Authors:
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Sean Munro |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cell Volume: 115 ISSN: 0092-8674 ISO Abbreviation: Cell Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-11-18 Completed Date: 2004-01-23 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 377-88 Citation Subset: IM |
Affiliation:
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MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom. sean@mrc-lmb.cam.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholesterol / metabolism Detergents / pharmacology Glycosylphosphatidylinositols / metabolism Humans Membrane Lipids / metabolism Membrane Microdomains / chemistry, drug effects, metabolism* Models, Biological* |
| Chemical | |
Reg. No./Substance:
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0/Detergents; 0/Glycosylphosphatidylinositols; 0/Membrane Lipids; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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