| Lipid profile in Portuguese obese children and adolescents: interaction of apolipoprotein E polymorphism with adiponectin levels. | |
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MedLine Citation:
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PMID: 19884594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate how the lipid profile associates with apolipoprotein (apo) E gene polymorphism, plasma adiponectin level, and body mass index (BMI) z score in Portuguese youth. DESIGN: Transversal cohort study. SETTING: Hospital de S??o Jo??o and Hospital de Crian??as Maria Pia, Porto, Portugal, between May 2006 and March 2007. PARTICIPANTS: One hundred thirty-eight obese children and adolescents (62 boys; mean age, 10.8 years [range, 4-16 years]). Participants were grouped according to (1) apo E polymorphism: presence of the apo E alleles 2 or 4 in E2 (n = 11) and E4 (n = 31) carriers, respectively, or as E3/E3 (n = 94) (carriers of E2/E4 [n = 2] were excluded from apo E analysis because they carry both alleles) and (2) BMI z score: group 1, BMI z score less than 2 (n = 31); group 2, BMI z score of 2 or more and less than 2.5 (n = 65); and group 3, BMI z score of 2.5 or more (n = 42). MAIN OUTCOME MEASURES: Lipid variable comparisons between apo E polymorphism and BMI z score groups and influence of BMI z score and adiponectin level, adjusted for apo E polymorphism, on total cholesterol to high-density lipoprotein cholesterol and apo A-I to apo B ratios. RESULTS: E4 carriers presented with a worse lipid profile when compared with E2 and E3/E3 carriers. There was also a clear risk of worsening for the group with the highest BMI z score. Apolipoprotein E polymorphism, BMI z score, and adiponectin level were significantly associated with total cholesterol to high-density lipoprotein cholesterol (standardized beta coefficient = 0.283, 0.354, and -0.292, respectively; P < .001 for all) and apo A-I to apo B (standardized beta coefficient = -0.372, -0.284, and 0.327, respectively; P < .001 for all) ratios. CONCLUSION: Our data suggest a more atherogenic lipid profile for some apo E genotypes and for increasing BMI z score, whereas adiponectin level seems to play a protective role. |
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Authors:
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Henrique Nascimento; Let??cia Silva; Pedro Louren??o; Radka Weinfurterov??; Elisabeth Castro; Carla Rego; Helena Ferreira; Ant??nio Guerra; Alexandre Quintanilha; Alice Santos-Silva; Lu??s Belo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of pediatrics & adolescent medicine Volume: 163 ISSN: 1538-3628 ISO Abbreviation: Arch Pediatr Adolesc Med Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-03 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9422751 Medline TA: Arch Pediatr Adolesc Med Country: United States |
Other Details:
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Languages: eng Pagination: 1030-6 Citation Subset: AIM; IM |
Affiliation:
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Departamento de Bioqu??mica, Faculdade de Farm??cia, Universidade do Porto, Porto, Portugal. henriqueferrao@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adolescent Age Factors Apolipoproteins E / genetics* Body Mass Index Child Child, Preschool Cohort Studies Cross-Sectional Studies Female Humans Lipids / blood* Male Obesity / blood* Polymorphism, Genetic* Portugal Waist Circumference Waist-Hip Ratio |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Apolipoproteins E; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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