| Lipid profile changes by high activity anti-retroviral therapy. | |
MedLine Citation:
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PMID: 23295258 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Study of the lipid profile in patients infected with HIV treated with different combinations of High Activity Anti-Retroviral Therapy (HAART). Design and Methods A retrospective cohort study of the lipid profile in patients undergoing HAART. The study analyses the evolution of concentrations of triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDLc) and HDL-cholesterol (HDLc) in a period of at least three years of treatment. From a total of 750 clinical cases analysed in Hospital Joaquim Urbano (Oporto, Portugal) 124 patients were selected for this study. RESULTS: After three years of treatment, we observed the development of dyslipidaemia by increases in TG (17%), TC (29%) and LDLc (9%), particularly in patients treated with a combination of drugs which included protease inhibitors (PI). Moreover, the Non-Nucleoside-Inhibitors of Reverse Transcriptase (NNRTI) were associated with better lipid profile. The increase of 46% in HDLc was the most surprising finding. CONCLUSIONS: he results indicate that patients with HAART have a more atherogenic lipidic profile with increased TC, LDLc and TG levels. Since the effectiveness of NNRTI is similar to that of PI, but with a smaller atherogenic profile, it should be the first choice drug to be selected in the HIV treatment. |
Authors:
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M Duro; R Sarmento-Castro; C Almeida; R Medeiros; I Rebelo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-4 |
Journal Detail:
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Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Faculty of Pharmacy, Oporto University, Oporto; Faculty of Health Sciences, Fernando Pessoa University, Oporto; Vale do Sousa Clinical Analysis Laboratory, Penafiel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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