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Lipid profile changes by high activity anti-retroviral therapy.
MedLine Citation:
PMID:  23295258     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Study of the lipid profile in patients infected with HIV treated with different combinations of High Activity Anti-Retroviral Therapy (HAART). Design and Methods A retrospective cohort study of the lipid profile in patients undergoing HAART. The study analyses the evolution of concentrations of triglycerides (TG), total cholesterol (TC), LDL-cholesterol (LDLc) and HDL-cholesterol (HDLc) in a period of at least three years of treatment. From a total of 750 clinical cases analysed in Hospital Joaquim Urbano (Oporto, Portugal) 124 patients were selected for this study. RESULTS: After three years of treatment, we observed the development of dyslipidaemia by increases in TG (17%), TC (29%) and LDLc (9%), particularly in patients treated with a combination of drugs which included protease inhibitors (PI). Moreover, the Non-Nucleoside-Inhibitors of Reverse Transcriptase (NNRTI) were associated with better lipid profile. The increase of 46% in HDLc was the most surprising finding. CONCLUSIONS: he results indicate that patients with HAART have a more atherogenic lipidic profile with increased TC, LDLc and TG levels. Since the effectiveness of NNRTI is similar to that of PI, but with a smaller atherogenic profile, it should be the first choice drug to be selected in the HIV treatment.
Authors:
M Duro; R Sarmento-Castro; C Almeida; R Medeiros; I Rebelo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Faculty of Pharmacy, Oporto University, Oporto; Faculty of Health Sciences, Fernando Pessoa University, Oporto; Vale do Sousa Clinical Analysis Laboratory, Penafiel.
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