| Lipid and polymeric carrier-mediated nucleic acid delivery. | |
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MedLine Citation:
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PMID: 20836625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IMPORTANCE OF THE FIELD: Nucleic acids such as plasmid DNA, antisense oligonucleotide, and RNA interference (RNAi) molecules, have a great potential to be used as therapeutics for the treatment of various genetic and acquired diseases. To design a successful nucleic acid delivery system, the pharmacological effect of nucleic acids, the physiological condition of the subjects or sites, and the physicochemical properties of nucleic acid and carriers have to be thoroughly examined. AREAS COVERED IN THIS REVIEW: The commonly used lipids, polymers and corresponding delivery systems are reviewed in terms of their characteristics, applications, advantages and limitations. What the reader will gain: This article aims to provide an overview of biological barriers and strategies to overcome these barriers by properly designing effective synthetic carriers for nucleic acid delivery. TAKE HOME MESSAGE: A thorough understanding of biological barriers and the structure-activity relationship of lipid and polymeric carriers is the key for effective nucleic acid therapy. |
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Authors:
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Lin Zhu; Ram I Mahato |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Expert opinion on drug delivery Volume: 7 ISSN: 1744-7593 ISO Abbreviation: Expert Opin Drug Deliv Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-22 Completed Date: 2011-02-18 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 101228421 Medline TA: Expert Opin Drug Deliv Country: England |
Other Details:
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Languages: eng Pagination: 1209-26 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 19 South Manassas St, Cancer Research Building RM 226, Memphis, TN 38103, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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DNA Drug Carriers / metabolism, pharmacology* Drug Delivery Systems Drug Design Lipids / administration & dosage*, chemistry Molecular Targeted Therapy Nucleic Acids / chemistry, pharmacology* Oligonucleotides, Antisense Plasmids Polymers / administration & dosage*, chemistry Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK069968-07/DK/NIDDK NIH HHS; R01 DK69968/DK/NIDDK NIH HHS; R01 EB003922/EB/NIBIB NIH HHS; R01 EB003922-04/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Lipids; 0/Nucleic Acids; 0/Oligonucleotides, Antisense; 0/Polymers; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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