Document Detail


Lipid phosphatases in the immune system.
MedLine Citation:
PMID:  10995586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the last 10 years we have come to appreciate the central role that phosphatidylinositol (PI)-3,4,5-P(3)plays in regulating a vast array of biological responses to extracellular signals. The level of this phospholipid is low in resting cells but increases rapidly in response to growth factor/cytokine-stimulated plasma membrane recruitment and activation of PI-3-kinase. Within the last 3 years three enzymes, SHIP, SHIP2 and PTEN, that play key roles in regulating the level of PI-3,4,5-P(3)have been cloned. In this review I have attempted to summarize our current knowledge regarding these three intriguing phosphatases.
Authors:
G Krystal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in immunology     Volume:  12     ISSN:  1044-5323     ISO Abbreviation:  Semin. Immunol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-10-30     Completed Date:  2000-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9009458     Medline TA:  Semin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  397-403     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Affiliation:
Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada V5Z 1L3. gerry@terryfox.ubc.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Immune System*
PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases / immunology*
Signal Transduction / immunology*
Tumor Suppressor Proteins*
Chemical
Reg. No./Substance:
0/Tumor Suppressor Proteins; EC 3.1.3.-/INPPL1 protein, human; EC 3.1.3.-/Phosphoric Monoester Hydrolases; EC 3.1.3.48/PTEN protein, human; EC 3.1.3.67/PTEN Phosphohydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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