Document Detail


Lipid peroxides, glutathione peroxidase, prostacyclin and cell cycle stages in normal and atherosclerotic Japanese quail arteries.
MedLine Citation:
PMID:  2653327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have previously shown a negative correlation between lipid peroxide levels and prostacyclin synthesis in plasma and artery of the atherosclerotic rabbit. Here we compare the arterial lipid peroxide content, glutathione peroxidase activity, and prostacyclin and thromboxane production in response to exogenous arachidonic acid stimulation, and the cell cycle stages in normal and atherogenic diet-fed quail. Lipid peroxides were higher in arteries of the atherosclerotic quail, while glutathione peroxidase activity and prostacyclin and thromboxane production were lower than that in the control quail. The smooth muscle cell cycle distribution which was determined by flow cytometry according to DNA content showed that more than 14% of atherosclerotic arteries were mitotically active (in S + G2 + M phase), while less than 10% of control cells were active. These results suggest that there is a close relationship between lipid peroxide content, prostacyclin production and cell proliferation of the arterial wall in experimental atherosclerotic quail.
Authors:
J Wang; Y C Lu; Z Z Guo; E Z Zhen; F Shi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Atherosclerosis     Volume:  75     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-06-06     Completed Date:  1989-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  219-25     Citation Subset:  IM    
Affiliation:
Research Section of Pharmacology, Human Medical University, Changsha The People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / cytology,  metabolism
Arteriosclerosis / metabolism*,  pathology
Cell Cycle
Cell Separation
Coturnix
Diet, Atherogenic
Epoprostenol / analysis*
Female
Flow Cytometry
Glutathione Peroxidase / analysis*
Lipid Peroxides / analysis*
Male
Chemical
Reg. No./Substance:
0/Lipid Peroxides; 35121-78-9/Epoprostenol; EC 1.11.1.9/Glutathione Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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