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Lipid peroxide levels and antioxidant status in alcoholic liver disease.
MedLine Citation:
PMID:  23105497     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The present study was conducted to evaluate some of the components of antioxidant defense system and oxidative damage in 20 male patients of alcoholic liver disease (ALD). The results were compared with 20 healthy male smokers and 20 healthy male non-smokers volunteers. Patients were subjected to detailed clinical examination and laboratory investigations. Blood samples were collected for estimating reduced glutathione (GSH), total thiols (T-SH) malondialdehyde (MDA), transaminases (AST, ALT), glutathione-S-transferease (GST) and gammaglutamyl transferase (GGT). Serum aspartate amino transferase (AST)/alanine amino transferase (ALT) ratio was significantly (p<0.01) reduced in ALD patients as compared to the controls. However, the core of utility of MDA and GST was found to be significantly (p<0.01) increased in ALD patients compared to controls. There was a significant negative correlation of MDA with both GSH and TSH. Plasma GGT levels were significantly (p<0.01) increased in alcoholics and the enzyme showed a significant positive correlation with MDA. These results give enough evidence of increased oxidative stress and compromised antioxidant defense system in patients with ALD.
Authors:
Seema Gupta; Rajesh Pandey; Ranjan Katyal; H K Aggarwal; R P Aggarwal; S K Aggarwal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of clinical biochemistry : IJCB     Volume:  20     ISSN:  0970-1915     ISO Abbreviation:  Indian J Clin Biochem     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2012-10-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8708303     Medline TA:  Indian J Clin Biochem     Country:  India    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  -    
Affiliation:
Department of Biochemistry, Lady Harding Medical College, New Delhi.
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