| Lipid peroxidation and scavenger mechanism in experimentally induced heart infarcts. | |
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MedLine Citation:
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PMID: 4074287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dog experiments were performed to describe the time course of lipid peroxidation after various ischemic influences of the heart measured by formation of malondialdehyde (MDA), and the scavenger action determined by reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Experimental groups consisted of control dogs having intact hearts and dogs with acute ramus descendens anterior ligature (LAD) having ischemic areas through 15, 30, 45 minutes and 1, 2, 3, 24 hours. Heart tissue for biochemical assays was excised from both the ischemic areas and from nonischemic left ventricle. The acute ischemia caused characteristic alterations in the biochemical parameters: MDA level gradually increased with its peak value being found at the end of 3 hours ligature. GSH levels decreased moderately, whereas SOD levels reduced sharply. As increased MDA formation indicates breakdown of the polyunsaturated fatty acids (PUFA) in the membranes and decreased GSH and SOD levels indicate impairment of the natural scavengering, the observed changes clearly outline the extent of disintegration of membrane structure and function. |
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Authors:
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E Röth; B Török; T Zsoldos; B Matkovics |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Basic research in cardiology Volume: 80 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1985 Sep-Oct |
Date Detail:
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Created Date: 1986-01-17 Completed Date: 1986-01-17 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 530-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / metabolism Antioxidants / pharmacology Coronary Disease / metabolism Dogs Fatty Acids, Unsaturated / metabolism Glutathione / metabolism Lipid Peroxides / biosynthesis* Malondialdehyde / metabolism Myocardial Infarction / drug therapy, metabolism* Superoxide Dismutase / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Fatty Acids, Unsaturated; 0/Lipid Peroxides; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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