Document Detail

Lipid peroxidation and scavenger mechanism in experimentally induced heart infarcts.
MedLine Citation:
PMID:  4074287     Owner:  NLM     Status:  MEDLINE    
Dog experiments were performed to describe the time course of lipid peroxidation after various ischemic influences of the heart measured by formation of malondialdehyde (MDA), and the scavenger action determined by reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Experimental groups consisted of control dogs having intact hearts and dogs with acute ramus descendens anterior ligature (LAD) having ischemic areas through 15, 30, 45 minutes and 1, 2, 3, 24 hours. Heart tissue for biochemical assays was excised from both the ischemic areas and from nonischemic left ventricle. The acute ischemia caused characteristic alterations in the biochemical parameters: MDA level gradually increased with its peak value being found at the end of 3 hours ligature. GSH levels decreased moderately, whereas SOD levels reduced sharply. As increased MDA formation indicates breakdown of the polyunsaturated fatty acids (PUFA) in the membranes and decreased GSH and SOD levels indicate impairment of the natural scavengering, the observed changes clearly outline the extent of disintegration of membrane structure and function.
E Röth; B Török; T Zsoldos; B Matkovics
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  80     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1985 Sep-Oct
Date Detail:
Created Date:  1986-01-17     Completed Date:  1986-01-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  530-6     Citation Subset:  IM    
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MeSH Terms
Anoxia / metabolism
Antioxidants / pharmacology
Coronary Disease / metabolism
Fatty Acids, Unsaturated / metabolism
Glutathione / metabolism
Lipid Peroxides / biosynthesis*
Malondialdehyde / metabolism
Myocardial Infarction / drug therapy,  metabolism*
Superoxide Dismutase / metabolism
Time Factors
Reg. No./Substance:
0/Antioxidants; 0/Fatty Acids, Unsaturated; 0/Lipid Peroxides; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; EC Dismutase

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