Document Detail


Lipid peroxidation: a possible factor in late graft failure of coronary artery bypass grafts.
MedLine Citation:
PMID:  2027203     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherosclerosis is the paramount cause of late vein graft failure after coronary artery bypass grafting. Lipid peroxidation, which may play a significant role in the initiation and progression of atherosclerosis, was examined in segments of vein grafts (n = 6) harvested at reoperation for coronary disease. These were analyzed for cholesterol, phospholipid, triglyceride, and lipid peroxides. Nonatherosclerotic vascular tissues, including coronary arteries (n = 6), saphenous veins (n = 9), and donor aortic specimens (n = 11) were analyzed for comparison. Risk factors for atherosclerosis including elevated serum cholesterol and triglycerides, smoking, and hypertension were more frequent in patients with coronary artery disease compared to organ donors. Lipid peroxides were elevated in explanted vein grafts when compared to either saphenous vein, coronary artery or donor aorta. Lipid peroxides were not significantly different in saphenous vein when compared to coronary artery, but levels in both of these tissues were greater than in donor aorta. Although increased levels of lipid peroxides in explanted veins may simply reflect morphologic changes in these grafts, the known effects of lipid peroxides on a number of biochemical events suggest that they may contribute directly to graft failure after coronary artery bypass grafting.
Authors:
J J Pitrowski; G C Hunter; C D Eskelson; G K Sethi; J C Copeland; K E McIntyre; E D Cottrell; M L Aguirre; V M Bernhard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  13     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1991 May 
Date Detail:
Created Date:  1991-06-13     Completed Date:  1991-06-13     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  652-8     Citation Subset:  IM    
Affiliation:
University of Arizona Health Sciences Center, Tucson.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aorta / chemistry
Cholesterol / analysis
Coronary Artery Bypass*
Coronary Artery Disease / metabolism*
Coronary Vessels / chemistry
Female
Humans
Lipid Peroxidation / physiology*
Lipid Peroxides / analysis
Male
Middle Aged
Phospholipids / analysis
Reoperation
Saphenous Vein / chemistry,  pathology,  transplantation*
Triglycerides / analysis
Chemical
Reg. No./Substance:
0/Lipid Peroxides; 0/Phospholipids; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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