Document Detail

Lipid peroxidation is not increased in heart failure patients on modern pharmacological therapy.
MedLine Citation:
PMID:  16310262     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies support a role of oxygen-free radicals in the development of congestive heart failure (CHF). The aim of this study was to investigate whether lipid peroxidation is increased in CHF patients on modern pharmacological therapy and whether there is a positive correlation between plasma levels of markers of lipid peroxidation and severity of heart failure (HF). Plasma malondialdehyde (MDA) and isoprostanes are often used as markers of lipid peroxidation and oxidative stress. We also studied whether long-term treatment with isosorbide-5-mononitrate (IS-5-MN) in combination with standard HF therapy affects P-MDA levels in patients with evidence of left ventricular (LV) dysfunction following acute myocardial infarction (AMI). MATERIALS AND METHODS: Ninety-two patients with clinical or echocardiographic evidence of LV-dysfunction following AMI were randomized to treatment with either IS-5-MN or placebo. In a subgroup of 83 patients with available plasma MDA, echocardiography, right-heart catherization, and plasma natriuretic peptides were evaluated. Control subjects were 80 healthy blood donors. A second study group consisted of 56 patients with CHF, evaluated with respect to LV function, brain natriuretic peptide and markers of oxidative stress (P-MDA and 8-isoprostane). The second control group comprised 50 healthy subjects. RESULTS: Lipid peroxidation measured by P-MDA and 8-isoprostane was not increased in patients with LV dysfunction treated with standard HF therapy. No positive correlation was found to the severity of HF. Long-term IS-5-MN therapy did not influence P-MDA concentrations. CONCLUSIONS: Although results from many experimental and clinical studies suggest that oxidative stress is increased in HF, this may not be true for patients treated with beta blockers and inhibitors of the renin-angiotensin system.
Erik Tingberg; Ann-Kristin Ohlin; Anders Gottsäter; Hans Ohlin
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2005-11-28
Journal Detail:
Title:  International journal of cardiology     Volume:  112     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2006-10-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  275-81     Citation Subset:  IM    
Department of Cardiology, University Hospital, SE-221 85 Lund, Sweden.
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MeSH Terms
Aged, 80 and over
Angiotensin II Type 1 Receptor Blockers / blood
Angiotensin-Converting Enzyme Inhibitors
Atrial Natriuretic Factor / blood
Captopril / therapeutic use
Delayed-Action Preparations
Dinoprost / analogs & derivatives,  blood
Heart Failure / drug therapy*,  epidemiology,  metabolism*,  ultrasonography
Isosorbide Dinitrate / administration & dosage,  analogs & derivatives*,  therapeutic use
Lipid Peroxidation*
Losartan / therapeutic use
Malondialdehyde / blood
Middle Aged
Myocardial Infarction / blood
Natriuretic Peptide, Brain / blood
Nitric Oxide Donors / administration & dosage,  therapeutic use*
Oxidative Stress / physiology
Ramipril / therapeutic use
Stroke Volume
Ventricular Dysfunction, Left / blood*,  epidemiology
Reg. No./Substance:
0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Delayed-Action Preparations; 0/Nitric Oxide Donors; 114471-18-0/Natriuretic Peptide, Brain; 114798-26-4/Losartan; 16051-77-7/isosorbide-5-mononitrate; 27415-26-5/8-epi-prostaglandin F2alpha; 542-78-9/Malondialdehyde; 551-11-1/Dinoprost; 62571-86-2/Captopril; 85637-73-6/Atrial Natriuretic Factor; 87-33-2/Isosorbide Dinitrate; 87333-19-5/Ramipril

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