| Lipid peroxidation is not increased in heart failure patients on modern pharmacological therapy. | |
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MedLine Citation:
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PMID: 16310262 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous studies support a role of oxygen-free radicals in the development of congestive heart failure (CHF). The aim of this study was to investigate whether lipid peroxidation is increased in CHF patients on modern pharmacological therapy and whether there is a positive correlation between plasma levels of markers of lipid peroxidation and severity of heart failure (HF). Plasma malondialdehyde (MDA) and isoprostanes are often used as markers of lipid peroxidation and oxidative stress. We also studied whether long-term treatment with isosorbide-5-mononitrate (IS-5-MN) in combination with standard HF therapy affects P-MDA levels in patients with evidence of left ventricular (LV) dysfunction following acute myocardial infarction (AMI). MATERIALS AND METHODS: Ninety-two patients with clinical or echocardiographic evidence of LV-dysfunction following AMI were randomized to treatment with either IS-5-MN or placebo. In a subgroup of 83 patients with available plasma MDA, echocardiography, right-heart catherization, and plasma natriuretic peptides were evaluated. Control subjects were 80 healthy blood donors. A second study group consisted of 56 patients with CHF, evaluated with respect to LV function, brain natriuretic peptide and markers of oxidative stress (P-MDA and 8-isoprostane). The second control group comprised 50 healthy subjects. RESULTS: Lipid peroxidation measured by P-MDA and 8-isoprostane was not increased in patients with LV dysfunction treated with standard HF therapy. No positive correlation was found to the severity of HF. Long-term IS-5-MN therapy did not influence P-MDA concentrations. CONCLUSIONS: Although results from many experimental and clinical studies suggest that oxidative stress is increased in HF, this may not be true for patients treated with beta blockers and inhibitors of the renin-angiotensin system. |
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Authors:
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Erik Tingberg; Ann-Kristin Ohlin; Anders Gottsäter; Hans Ohlin |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2005-11-28 |
Journal Detail:
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Title: International journal of cardiology Volume: 112 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-25 Completed Date: 2006-10-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 275-81 Citation Subset: IM |
Affiliation:
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Department of Cardiology, University Hospital, SE-221 85 Lund, Sweden. erik.tingberg@skane.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Angiotensin II Type 1 Receptor Blockers / blood Angiotensin-Converting Enzyme Inhibitors Atrial Natriuretic Factor / blood Captopril / therapeutic use Comorbidity Delayed-Action Preparations Dinoprost / analogs & derivatives, blood Female Heart Failure / drug therapy*, epidemiology, metabolism*, ultrasonography Hemodynamics Humans Isosorbide Dinitrate / administration & dosage, analogs & derivatives*, therapeutic use Lipid Peroxidation* Losartan / therapeutic use Male Malondialdehyde / blood Middle Aged Myocardial Infarction / blood Natriuretic Peptide, Brain / blood Nitric Oxide Donors / administration & dosage, therapeutic use* Oxidative Stress / physiology Ramipril / therapeutic use Stroke Volume Ventricular Dysfunction, Left / blood*, epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin II Type 1 Receptor Blockers; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Delayed-Action Preparations; 0/Nitric Oxide Donors; 114471-18-0/Natriuretic Peptide, Brain; 114798-26-4/Losartan; 16051-77-7/isosorbide-5-mononitrate; 27415-26-5/8-epi-prostaglandin F2alpha; 542-78-9/Malondialdehyde; 551-11-1/Dinoprost; 62571-86-2/Captopril; 85637-73-6/Atrial Natriuretic Factor; 87-33-2/Isosorbide Dinitrate; 87333-19-5/Ramipril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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