Document Detail

Lipid peroxidation level and antioxidant enzyme activities in the blood of patients with acute and chronic fascioliasis.
MedLine Citation:
PMID:  16859944     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In this study, we investigated the relationship between fascioliasis and serum malondialdehyde (MDA) levels, superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities. We also investigated whether there are significant differences in MDA levels and antioxidant enzymatic activities between acute and chronic fascioliasis. METHODS: Forty fascioliasis patients who were diagnosed by ES-ELISA positivity were included in this study. The patients were classified as 18 with acute and 22 with chronic fascioliasis. RESULTS: In patients with fascioliasis, levels of MDA were statistically higher and erythrocyte SOD and GPx activities were statistically lower than in healthy controls. MDA levels were found to be higher in patients with acute fascioliasis than in patients with chronic fascioliasis although MDA levels were significantly higher in patients with chronic fascioliasis than in controls. There was no statistically significant difference between the two groups for the antioxidant enzyme activities. CONCLUSION: The results of this study may indicate that fascioliasis produces specific effects on the antioxidant defense mechanisms due to its inflammatory character. Our results also allow us to suggest that oxidative stress has an important role in the pathogenesis of fascioliasis and the persistence of this oxidative stress can be one of the underlying factors in the pathogenesis of the chronic disease.
Selçuk Kaya; Recep Sütçü; Emel Sesli Cetin; Buket Cicioglu Aridogan; Namik Delibaş; Mustafa Demirci
Related Documents :
17130274 - Inflammatory syndrome in patients on hemodialysis.
15957544 - Lymphocyte 5'-nucleotidase and aminopeptidase n activity in patients on maintenance hem...
21544854 - Thyroid abnormalities in patients treated with lenalidomide for hematological malignanc...
15356964 - Plasma leptin concentration in patients with acute renal failure.
8591714 - Metabolic regulation and microangiopathy in a cohort of japanese iddm-patients.
2148354 - Comparative study of dilated cardiomyopathy and specific heart muscle diseases from pat...
Publication Detail:
Type:  Journal Article     Date:  2006-07-21
Journal Detail:
Title:  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases     Volume:  11     ISSN:  1201-9712     ISO Abbreviation:  Int. J. Infect. Dis.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610933     Medline TA:  Int J Infect Dis     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  251-5     Citation Subset:  IM    
Department of Microbiology, Medicine Faculty, Suleyman Demirel University, Isparta, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Catalase / blood*
Chronic Disease
Fascioliasis / blood*,  enzymology
Glutathione Peroxidase / blood*
Lipid Peroxidation*
Malondialdehyde / blood*
Middle Aged
Oxidative Stress*
Superoxide Dismutase / blood*
Reg. No./Substance:
542-78-9/Malondialdehyde; EC; EC Peroxidase; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Metastatic squamous cell carcinoma in a cat.
Next Document:  Distribution and epidemiology of Candida species causing fungemia at a Saudi Arabian hospital, 1996-...