| Lipid peroxidation intensity and lipid status parameters in the estimation of the severity of ischemic heart disease. | |
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MedLine Citation:
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PMID: 9769734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerotic changes on the coronary arteries are the basis of the ischemic heart disease. It is assumed that the initial changes in this process occur as a consequence of the lipid peroxidation in the vessel wall. We estimated this process through the level of malondialdehyde (MDA) in the serum of 86 patients in whom selective coronary angiography was done for the suspected ischemic heart disease. According to the number of the stenotic coronary arteries (stenosis greater than 50%), we divided the patients into four groups: the control group with normal coronary angiography finding, simple, double or triple vessel coronary disease. In all the patients we also estimated the other parameters of the lipid status (cholesterol, triglycerides, LDL, HDL, Apo-AI, Apo B) and atherogenic indices Apo-AI/Apo B, LDL/HDL and HDL/total cholesterol. No significant changes were observed in the lipid parameters between the control and experimental group. However, mean MDA level in the whole experimental group was 3.89 mumol/L, 3.93 mumol/L in triple vessel coronary disease, 3.83 mumol/L in double vessel and 3.92 mumol/L in single vessel disease group. The difference between all the experimental and the control group was highly significant (p < 0.001). We concluded that the level of MDA--lipid peroxidation index had the better correlation with the disease status than the other parameters of lipid status and the sensitive atherogenic indices. |
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Authors:
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D Dincić; P Jović; S Obradović; P Popović; M Prcović |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Vojnosanitetski pregled. Military-medical and pharmaceutical review Volume: 55 ISSN: 0042-8450 ISO Abbreviation: Vojnosanit Pregl Publication Date: 1998 Jul-Aug |
Date Detail:
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Created Date: 1998-11-13 Completed Date: 1998-11-13 Revised Date: 2008-01-09 |
Medline Journal Info:
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Nlm Unique ID: 21530700R Medline TA: Vojnosanit Pregl Country: YUGOSLAVIA |
Other Details:
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Languages: eng Pagination: 359-67 Citation Subset: IM |
Affiliation:
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Clinic for Cardiology, Belgrade. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Coronary Angiography Coronary Artery Disease / metabolism*, radiography Female Humans Lipid Peroxidation* Lipids / blood* Male Malondialdehyde / blood Middle Aged Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 542-78-9/Malondialdehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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