| Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model. | |
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MedLine Citation:
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PMID: 8937879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An integrative mathematical model was developed to obtain an overall picture of lipid hydroperoxide metabolism in the mitochondrial inner membrane and surrounding matrix environment. The model explicitly considers an aqueous and a membrane phase, integrates a wide set of experimental data, and unsupported assumptions were minimized. The following biochemical processes were considered: the classic reactional scheme of lipid peroxidation; antioxidant and pro-oxidant effects of vitamin E; pro-oxidant effects of iron; action of phospholipase A2, glutathione-dependent peroxidases, glutathione reductase and superoxide dismutase; production of superoxide radicals by the mitochondrial respiratory chain; oxidative damage to proteins and DNA. Steady-state fluxes and concentrations as well as half-lives and mean displacements for the main metabolites were calculated. A picture of lipid hydroperoxide physiological metabolism in mitochondria in vivo showing the main pathways is presented. The main results are: (a) perhydroxyl radical is the main initiation agent of lipid peroxidation (with a flux of 10(-7)MS-1); (b) vitamin E efficiently inhibits lipid peroxidation keeping the amplification (kinetic chain length) of lipid peroxidation at low values (approximately equal to 10); (c) only a very minor fraction of lipid hydroperoxides escapes reduction via glutathione-dependent peroxidases; (d) oxidized glutathione is produced mainly from the reduction of hydrogen peroxide and not from the reduction of lipid hydroperoxides. |
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Authors:
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F Antunes; A Salvador; H S Marinho; R Alves; R E Pinto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical biology & medicine Volume: 21 ISSN: 0891-5849 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 1996 |
Date Detail:
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Created Date: 1997-02-19 Completed Date: 1997-02-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 917-43 Citation Subset: IM |
Affiliation:
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Grupo de Bioquímica e Biologia Teóricas, Instituto de Investigação Científica, Bento da Rocha Cabral, Lisboa, Portugal. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiolipins
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metabolism Glutathione / metabolism Iron / pharmacology Kinetics Lipid Peroxidation / physiology* Lipid Peroxides / metabolism Membrane Lipids / metabolism* Mitochondria / metabolism* Models, Chemical Oxygen / metabolism Reactive Oxygen Species / metabolism Vitamin E / metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cardiolipins; 0/Lipid Peroxides; 0/Membrane Lipids; 0/Reactive Oxygen Species; 1406-18-4/Vitamin E; 70-18-8/Glutathione; 7439-89-6/Iron; 7782-44-7/Oxygen |
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