| Lipid peroxidation and antioxidant defense impairment in the hearts of chick embryos induced by in ovo exposure to Fusarium mycotoxin butenolide. | |
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MedLine Citation:
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PMID: 18775738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fusarium mycotoxin toxicosis has been implicated as an etiological factor for Keshan disease, an endemic cardiomyopathy prevailing in specific regions of China. Butenolide (4-acetamido-4-hydroxy-2-butenoic acid gamma-lactone) is one of the Fusarium mycotoxins frequently detected from the foodstuffs of endemic areas and has been shown to possess the potential to induce cardiotoxicity, implying this mycotoxin might play a role in the occurrence of Keshan disease. The present study was undertaken to further investigate the myocardial toxicity of butenolide from a viewpoint of oxidative damage. A single in ovo injection of butenolide to chick embryos, an excellent in vitro toxicology model resulted in significant oxidative injuries to the myocardium, manifested by a dose-dependent depletion of sulfhydryl groups, reduction of glutathione peroxidase (GPx) activity, and increase of thiobarbituric acid reactive substances production, a hallmark of lipid peroxidation. In contrast, co-injections of butenolide to chick embryos with sodium selenite or vitamin C, two potent antioxidants, markedly abated these oxidative injuries. In conclusion, the present study clearly indicated that butenolide could induce significant myocardial oxidative injuries. The current findings reinforce the hypothesis that toxicosis by Fusarium mycotoxins may be one of the etiological factors for Keshan disease, and oxidative damage is involved in the pathogenesis of myocardial toxicity. |
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Authors:
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Yi-Mei Wang; Hui-Jiao Wang; Shuang-Qing Peng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-19 |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: 52 ISSN: 0041-0101 ISO Abbreviation: Toxicon Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2009-01-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: England |
Other Details:
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Languages: eng Pagination: 781-6 Citation Subset: IM |
Affiliation:
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Evaluation and Research Center for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, 109 Xiaotun Road, Fengtai District, Beijing 100071, PR China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Butyrolactone
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analogs & derivatives*,
chemistry,
toxicity Animals Antioxidants / pharmacology, physiology* Ascorbic Acid / pharmacology Chick Embryo Embryo, Nonmammalian / drug effects* Fusarium / chemistry Glutathione Peroxidase / metabolism Heart / drug effects*, embryology Lipid Peroxidation / drug effects* Mycotoxins / toxicity* Oxidative Stress / drug effects Sodium Selenite / pharmacology Sulfhydryl Compounds / metabolism Toxicity Tests |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Mycotoxins; 0/Sulfhydryl Compounds; 10102-18-8/Sodium Selenite; 497-23-4/butenolide; 50-81-7/Ascorbic Acid; 96-48-0/4-Butyrolactone; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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