Document Detail


Lipid peroxidation and the aging process.
MedLine Citation:
PMID:  14603026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Consistent evidence supports the hypothesis that a progressive accumulation of oxidative damage to important cellular molecules is a fundamental mechanism involved in most senescence-associated alterations. Oxidative damage occurs when free radicals produced within an organism are not completely destroyed by the appropriate endogenous defense systems. Because lipids are a major component of living organisms and probably the first easy target of free radicals once they are produced, lipid peroxidation might play an important role in initiating and/or mediating some aspects of the aging process. It has been widely demonstrated that there is an age-associated increase in the steady-state concentrations of lipid peroxidation products. However, establishing the involvement of this phenomenon in the pathogenesis of the aging process has not been an easy task. The recent development of more reliable techniques to measure lipid peroxidation, together with more well-defined animal models of aging, should be of great help in future studies in this field. The current evidence for the presence and importance of lipid peroxidation in the aging process is discussed in this review.
Authors:
Domenico Praticò
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Publication Detail:
Type:  Journal Article; Review     Date:  2002-12-18
Journal Detail:
Title:  Science of aging knowledge environment : SAGE KE     Volume:  2002     ISSN:  1539-6150     ISO Abbreviation:  Sci Aging Knowledge Environ     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-11-06     Completed Date:  2003-11-07     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  101146039     Medline TA:  Sci Aging Knowledge Environ     Country:  United States    
Other Details:
Languages:  eng     Pagination:  re5     Citation Subset:  IM    
Affiliation:
Center for Experimental Therapeutics, Department of Pharmacology at the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. domenico@spirit.gcrc.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism*
Animals
Free Radicals / metabolism
Humans
Lipid Metabolism
Lipid Peroxidation / physiology*
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Free Radicals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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