Document Detail

Lipid peroxidation and 5-lipoxygenase activity in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  15579728     Owner:  NLM     Status:  MEDLINE    
We studied the urinary excretion of the isoprostane 8-iso-prostaglandin F(2alpha) as an index of in vivo oxidant stress, and the production of leukotriene (LT) B(4) (LTB(4)) by neutrophils in subjects with chronic obstructive pulmonary disease (COPD) and normal subjects. Overnight urinary excretion of the isoprostane was significantly higher in patients with COPD than in control subjects, and LTB(4) production by challenge of neutrophils obtained from patients with COPD was also significantly higher than that observed in control neutrophils. Treatment with a standardized polyphenol extract caused a significant decrease in isoprostane excretion, accompanied by a statistically significant increase of Pa(O(2)). Furthermore, changes in FEV(1) significantly correlated with the changes in isoprostane urinary excretion observed from enrollment to the end of treatment. The results of this study suggest that enhanced oxidative stress in subjects with COPD is paralleled by the increased ability of neutrophils to synthesize the chemotactic factor LTB(4), and may ultimately contribute to the infiltration/activation of neutrophils into the airways of subjects with COPD. Antioxidant treatment in subjects with COPD is effective in reducing oxidant stress as shown by the decrease of urinary isoprostane, a reduction that correlates with the severity of the disease, as indicated by changes in Pa(O(2)) and FEV(1).
Pierachille Santus; Alessandra Sola; Paolo Carlucci; Francesca Fumagalli; Antonio Di Gennaro; Michele Mondoni; Chiara Carnini; Stefano Centanni; Angelo Sala
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article     Date:  2004-12-03
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  171     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-08     Completed Date:  2006-06-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  838-43     Citation Subset:  AIM; IM    
Department of Pharmacological Sciences, Center for Cardiopulmonary Pharmacology, Via Balzaretti 9, Milan 20133, Italy.
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MeSH Terms
Arachidonate 5-Lipoxygenase / metabolism*
Forced Expiratory Volume / drug effects
Isoprostanes / urine
Leukotriene B4 / metabolism
Lipid Peroxidation / drug effects,  physiology*
Middle Aged
Neutrophils / physiology
Oxidative Stress / physiology
Oxygen / blood
Plant Extracts / therapeutic use
Pulmonary Disease, Chronic Obstructive / diagnosis,  drug therapy,  physiopathology*
Reference Values
Reg. No./Substance:
0/Isoprostanes; 0/Plant Extracts; 0/isoprostane F2alpha III; 71160-24-2/Leukotriene B4; 7782-44-7/Oxygen; EC 5-Lipoxygenase

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