| Lipid and non-lipid effects of statins. | |
| | |
MedLine Citation:
|
PMID: 16596807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Long- and short-term trials with the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have demonstrated significant reductions in cardiovascular events in patients with and without history of coronary heart disease. Statins are well-established low-density lipoprotein (LDL)-lowering agents, but their clinical benefit is believed to result from a number of lipid and non-lipid effects beyond LDL lowering, including a rise in plasma high-density lipoprotein levels. Beyond improving the lipid profile, statins have additional non-lipid effects including benefit on endothelial function, inflammatory mediators, intima-media thickening, prothombotic factors that ultimately result in plaque stabilization. These effects arise through the inhibition of several mevalonate-derived metabolites other than cholesterol itself, which are involved in the control of different cellular functions. Although statins represent the gold standard in the prevention and treatment of coronary heart disease, combination therapy with other lipid-lowering drugs, as well as novel therapeutic indications, may increase their therapeutic potential. |
| | |
Authors:
|
R Paoletti; C Bolego; A Cignarella |
Related Documents
:
|
6740187 - The bucharest multifactorial prevention trial of coronary heart disease--ten year follo... 15150487 - Statins and secondary prevention of coronary heart disease. 6331147 - Cardiovascular features of homozygous familial hypercholesterolemia: analysis of 16 pat... 15757077 - Effect of preexisting statin use on expression of c-reactive protein, adhesion molecule... 20425747 - Multiple embolisations in rheumatic heart disease: a case report. 421547 - The advantages of open mitral commissurotomy for mitral stenosis. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Handbook of experimental pharmacology Volume: - ISSN: 0171-2004 ISO Abbreviation: Handb Exp Pharmacol Publication Date: 2005 |
Date Detail:
|
Created Date: 2006-04-06 Completed Date: 2006-04-19 Revised Date: 2007-05-15 |
Medline Journal Info:
|
Nlm Unique ID: 7902231 Medline TA: Handb Exp Pharmacol Country: Germany |
Other Details:
|
Languages: eng Pagination: 365-88 Citation Subset: IM |
Affiliation:
|
Department of Pharmacological Sciences, University of Milan, Italy. rodolfo.paoletti@unimi.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anticholesteremic Agents / pharmacology* Atherosclerosis / drug therapy* C-Reactive Protein / analysis Endothelium, Vascular / physiology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*, therapeutic use Lipoprotein(a) / blood Lipoproteins, HDL / blood Lipoproteins, LDL / blood, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Anticholesteremic Agents; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipoprotein(a); 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alcohol.
Next Document: Fibrates.