| Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans. | |
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MedLine Citation:
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PMID: 15741263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Atrial natriuretic peptide (ANP) in pharmacological concentrations stimulates lipid mobilization in humans. OBJECTIVE: The objective was to determine the hemodynamic and metabolic response to physiologically relevant ANP concentrations. DESIGN: The design was a human physiological study, conducted in 2004. SETTING: The study was conducted at an academic research institute. PARTICIPANTS: Fourteen healthy normal-weight men (30 +/- 1.2 yr) participated in the study. Intervention: Intravenous infusion of human ANP (h-ANP) was administered at rates of 6.25, 12.5, and 25 ng/kg.min. MAIN OUTCOME MEASURES: We studied local changes in blood flow and glucose and lipid metabolism of abdominal sc adipose tissue and femoral skeletal muscle by microdialysis. Overall changes in energy expenditure and substrate oxidation rates were monitored by indirect calorimetry. RESULTS: The increase in serum nonesterified fatty acids and glycerol concentrations were correlated with ANP plasma concentrations (r(2) = 0.86 and r(2) = 0.76, respectively). In adipose tissue, glycerol increased from 53 +/- 6 micromol/liter to 87+/-13 micromol/liter (P < 0.001). In femoral skeletal muscle, glycerol concentrations did not change, whereas lactate-to-pyruvate ratio decreased from 91 +/- 23 to 32 +/- 4 (P < 0.001). Indirect calorimetry indicated an increase in lipid oxidation (P < 0.05) concomitantly with a decrease in carbohydrate oxidation (P < 0.01), without changes in overall energy expenditure. CONCLUSIONS: ANP briskly stimulates lipid mobilization and oxidation at plasma concentrations that are encountered in conditions such as heart failure. Natriuretic-peptide induced lipid mobilization might contribute to cardiac cachexia. Drugs that interfere with the natriuretic peptide system should be evaluated for potential metabolic side effects. |
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Authors:
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Andreas L Birkenfeld; Michael Boschmann; Cedric Moro; Frauke Adams; Karsten Heusser; Gabriele Franke; Michel Berlan; Friedrich C Luft; Max Lafontan; Jens Jordan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-03-01 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 90 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-26 Completed Date: 2005-07-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 3622-8 Citation Subset: AIM; IM |
Affiliation:
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Franz-Volhard Clinical Research Center, Haus 129, Charité Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects,
metabolism Adult Atrial Natriuretic Factor / administration & dosage, pharmacology* Blood Pressure / drug effects Ethanol / blood Fatty Acids, Nonesterified / blood Hemodynamics Humans Infusions, Intravenous Lactates / blood Lipid Mobilization / drug effects* Male Microdialysis Muscle, Skeletal / drug effects, metabolism Reference Values Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Nonesterified; 0/Lactates; 0/Triglycerides; 64-17-5/Ethanol; 85637-73-6/Atrial Natriuretic Factor |
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