Document Detail


Lipid microsphere containing lipophilic heme: preparation and oxygen transportation under physiological conditions.
MedLine Citation:
PMID:  1637849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipophilic heme (1-laurylimidazole-ligated 5,10,15,20-tetrakis(alpha, alpha, alpha, alpha-o- pivalamidophenyl)porphinatoiron(II) complex) is solubilized in lipid (triglyceride) at high concentrations and emulsified with a phospholipid in physiological salt solution, giving a deeply red-colored suspension of lipid microspheres (approx. 250 nm in diameter). The heme forms an oxygen adduct in a similar manner as oxyhemoglobin and the lipid microspheres take up and release oxygen reversibly at 37 degrees C in the aqueous medium. The oxygen-transporting ability is comparable with that of the red blood cell. Intravenous injection of the heme/lipid microsphere solution to rabbits demonstrates that it transports oxygen even in vivo and that it is cleared from the blood stream with a half-life time of approx. 1 h.
Authors:
E Tsuchida; H Nishide; T Komatsu; K Yamamoto; E Matsubuchi; K Kobayashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1108     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-31     Completed Date:  1992-08-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  253-6     Citation Subset:  IM    
Affiliation:
Department of Polymer Chemistry, Waseda University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Carriers
Half-Life
Heme* / analysis
Lipids*
Microspheres*
Molecular Structure
Oxygen* / chemistry,  metabolism
Rabbits
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Lipids; 14875-96-8/Heme; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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