| Lipid metabolites in the pathogenesis and treatment of neovascular eye disease. | |
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MedLine Citation:
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PMID: 21421650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipids and lipid metabolites have long been known to play biological roles that go beyond energy storage and membrane structure. In age-related macular degeneration and diabetes, for example, dysregulation of lipid metabolism is closely associated with disease onset and progression. At the same time, some lipids and their metabolites can exert beneficial effects in the same disorders. This review summarises our current knowledge of the contributions of lipids to both the pathogenesis and treatment of neovascular eye disease. The clinical entities covered are exudative age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity, with a special emphasis on the potential therapeutic effects of ω3- (also known as n-3) polyunsaturated fatty acids. |
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Authors:
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Andreas Stahl; Tim U Krohne; Przemyslaw Sapieha; Jing Chen; Ann Hellstrom; Emily Chew; Frank G Holz; Lois E H Smith |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-03-18 |
Journal Detail:
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Title: The British journal of ophthalmology Volume: 95 ISSN: 1468-2079 ISO Abbreviation: Br J Ophthalmol Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-24 Completed Date: 2011-12-20 Revised Date: 2013-05-16 |
Medline Journal Info:
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Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
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Languages: eng Pagination: 1496-501 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Diabetic Retinopathy
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drug therapy,
physiopathology Eye / blood supply* Fatty Acids, Unsaturated / therapeutic use Humans Infant, Newborn Infant, Premature Lipid Metabolism / physiology* Lipid Peroxidation / physiology Macular Degeneration / drug therapy, physiopathology Neovascularization, Pathologic / drug therapy, physiopathology* Retinopathy of Prematurity / drug therapy, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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EY017017/EY/NEI NIH HHS; EY017017-S1/EY/NEI NIH HHS; R01 EY017017/EY/NEI NIH HHS; R01 EY022275/EY/NEI NIH HHS; //Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Unsaturated |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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