Document Detail


Lipid metabolites in the pathogenesis and treatment of neovascular eye disease.
MedLine Citation:
PMID:  21421650     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipids and lipid metabolites have long been known to play biological roles that go beyond energy storage and membrane structure. In age-related macular degeneration and diabetes, for example, dysregulation of lipid metabolism is closely associated with disease onset and progression. At the same time, some lipids and their metabolites can exert beneficial effects in the same disorders. This review summarises our current knowledge of the contributions of lipids to both the pathogenesis and treatment of neovascular eye disease. The clinical entities covered are exudative age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity, with a special emphasis on the potential therapeutic effects of ω3- (also known as n-3) polyunsaturated fatty acids.
Authors:
Andreas Stahl; Tim U Krohne; Przemyslaw Sapieha; Jing Chen; Ann Hellstrom; Emily Chew; Frank G Holz; Lois E H Smith
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-03-18
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  95     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-24     Completed Date:  2011-12-20     Revised Date:  2013-07-19    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1496-501     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Diabetic Retinopathy / drug therapy,  physiopathology
Eye / blood supply*
Fatty Acids, Unsaturated / therapeutic use
Humans
Infant, Newborn
Infant, Premature
Lipid Metabolism / physiology*
Lipid Peroxidation / physiology
Macular Degeneration / drug therapy,  physiopathology
Neovascularization, Pathologic / drug therapy,  physiopathology*
Retinopathy of Prematurity / drug therapy,  physiopathology
Grant Support
ID/Acronym/Agency:
EY017017/EY/NEI NIH HHS; EY017017-S1/EY/NEI NIH HHS; R01 EY017017/EY/NEI NIH HHS; R01 EY022275/EY/NEI NIH HHS; //Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Fatty Acids, Unsaturated
Comments/Corrections

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