Document Detail


Lipid metabolism and toxicity in the heart.
MedLine Citation:
PMID:  22682221     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The heart has both the greatest caloric needs and the most robust oxidation of fatty acids (FAs). Under pathological conditions such as obesity and type 2 diabetes, cardiac uptake and oxidation are not balanced and hearts accumulate lipid potentially leading to cardiac lipotoxicity. We will first review the pathways utilized by the heart to acquire FAs from the circulation and to store triglyceride intracellularly. Then we will describe mouse models in which excess lipid accumulation causes heart dysfunction and experiments performed to alleviate this toxicity. Finally, the known relationships between heart lipid metabolism and dysfunction in humans will be summarized.
Authors:
Ira J Goldberg; Chad M Trent; P Christian Schulze
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cell metabolism     Volume:  15     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-10-02     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  805-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Medicine, Columbia University, New York, NY 10032, USA. ijg3@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiomyopathies / etiology,  metabolism
Diabetes Mellitus, Type 2 / complications,  metabolism
Energy Metabolism
Fatty Acids / blood,  metabolism
Humans
Lipid Metabolism*
Myocardium / metabolism*,  pathology
Obesity / complications,  metabolism
Grant Support
ID/Acronym/Agency:
HL45095/HL/NHLBI NIH HHS; HL73029/HL/NHLBI NIH HHS; P30 HL101272/HL/NHLBI NIH HHS; R01 HL045095/HL/NHLBI NIH HHS; R01 HL073029/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fatty Acids
Comments/Corrections

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