Document Detail


Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men.
MedLine Citation:
PMID:  16219668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To discover the alterations in lipid metabolism linked to postexercise hypotriglyceridemia, we measured lipid kinetics, lipoprotein subclass distribution and lipid transfer enzymes in seven healthy, lean, young men the day after 2 h of cycling and rest. Compared with rest, exercise increased fatty acid rate of appearance and whole body fatty acid oxidation by approximately 65 and 40%, respectively (P < 0.05); exercise had no effect on VLDL-triglyceride (TG) secretion rate, increased VLDL-TG plasma clearance rate by 40 +/- 8%, and reduced VLDL-TG mean residence time by approximately 40 min and VLDL-apolipoprotein B-100 (apoB-100) secretion rate by 24 +/- 8% (all P < 0.05). Exercise also reduced the number of VLDL but almost doubled the number of IDL particles in plasma (P < 0.05). Muscle lipoprotein lipase content was not different after exercise and rest, but plasma lipoprotein lipase concentration increased by approximately 20% after exercise (P < 0.05). Plasma hepatic lipase and lecithin:cholesterol acyltransferase concentrations were not affected by exercise, whereas cholesterol ester transfer protein concentration was approximately 10% lower after exercise than after rest (P = 0.052). We conclude that 1) greater fatty acid availability after exercise does not stimulate VLDL-TG secretion, probably because of the increase in fatty acid oxidation and possibly also fatty acid use for restoration of tissue TG stores; 2) reduced secretion of VLDL-apoB-100 lowers plasma VLDL particle concentration; and 3) increased VLDL-TG plasma clearance maintains low plasma TG concentration but is not accompanied by similar increases in subsequent steps of the delipidation cascade. Acutely, therefore, the cardioprotective lowering of plasma TG and VLDL concentrations by exercise is counteracted by a proatherogenic increase in IDL concentration.
Authors:
Faidon Magkos; David C Wright; Bruce W Patterson; B Selma Mohammed; Bettina Mittendorfer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-10-11
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  290     ISSN:  0193-1849     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-11     Completed Date:  2006-02-22     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E355-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Exercise / physiology
Humans
Lipid Metabolism / physiology*
Male
Physical Endurance / physiology*
Physical Exertion / physiology
Reference Values
Grant Support
ID/Acronym/Agency:
AG-00078/AG/NIA NIH HHS; AR-49869/AR/NIAMS NIH HHS; DK-56341/DK/NIDDK NIH HHS; HD-01459/HD/NICHD NIH HHS; P30 DK056341/DK/NIDDK NIH HHS; P30 DK056341-05S2/DK/NIDDK NIH HHS; P30 DK056341-06/DK/NIDDK NIH HHS; RR-00036/RR/NCRR NIH HHS; RR-00954/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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