Document Detail

Lipid metabolism in spontaneously hypertensive rats (SHR).
MedLine Citation:
PMID:  23130     Owner:  NLM     Status:  MEDLINE    
Plasma cholesterol was lower in spontaneously hypertensive rats (SHR), while plasma triglyceride and free fatty acid were increased in comparison with control normotensive Wistar-Kyoto (WK) rats. Correspondingly, [1-14C]-acetate incorporation into liver cholesterol was clearly decreased in SHR as compared with WK. As for lipogenic enzyme activities, glucose-6-phosphate dehydrogenase, malic enzyme and acetyl-CoA carboxylase in SHR were respectively decreased, increased and not significantly different, in comparison with WK rats. Liver cholesterol was rather low and cardiac triglyceride was slightly increased in SHR. Aortic cholesterol and triglyceride levels were not significantly different between SHR AND WK rats. Thus, SHR have an abnormality in lipid metabolism, especially in cholesterol synthesis, but the pathological implication of this in hypertension and related vascular lesions is not yet clear.
N Iritani; E Fukuda; Y Nara; Y Yamori
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Atherosclerosis     Volume:  28     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1977 Nov 
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  217-22     Citation Subset:  IM    
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MeSH Terms
Acetyl-CoA Carboxylase / metabolism
Aorta / metabolism
Cholesterol / metabolism
Fatty Acids, Nonesterified / metabolism
Glucosephosphate Dehydrogenase / metabolism
Hypertension / metabolism*
Lipid Metabolism*
Liver / metabolism
Malate Dehydrogenase / metabolism
Myocardium / metabolism
Triglycerides / metabolism
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Triglycerides; 57-88-5/Cholesterol; EC Dehydrogenase; EC Dehydrogenase; EC Carboxylase

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