Document Detail

Lipid metabolism in the cockroach, Periplaneta americana, is activated by the hypertrehalosemic peptide, HTH-I.
MedLine Citation:
PMID:  14706533     Owner:  NLM     Status:  MEDLINE    
Phosphatidylcholine and phosphatidylethanolamine are the major constituents of the phospholipid pool in cockroach (Periplaneta americana) fat body and hemolymph. Both species of phospholipid are significantly decreased 6h after injecting hypertrehalosemic hormone I (HTH-I) into the hemocoel. Loss of phospholipid is accompanied by an accumulation of the phospholipid degradation products glycerophosphorylcholine and glycerol. HTH-I also increases phospholipase activity in the hemolymph and this is thought to be responsible for the depletion of hemolymph phospholipid. Phospholipase activity peaks approximately 2h after injection of HTH-I and returns to normal at 6h. In vitro, total phospholipid in the fat body is decreased by HTH-I whereas the concentration of diacylglycerol displays a corresponding increase. HTH-I elevates free fatty acid levels but has no effect on triacylglycerol. These effects of HTH-I are blocked by the phospholipase inhibitor mepacrine.
Elisha Oguri; John E Steele
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  24     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-01-06     Completed Date:  2005-01-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1545-51     Citation Subset:  IM    
Department of Biology, The University of Western Ontario, Ont., N6A 5B7, London, Canada.
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MeSH Terms
Enzyme Activation / drug effects
Fat Body / chemistry,  drug effects,  metabolism
Hemolymph / chemistry,  drug effects,  enzymology,  metabolism
Lipid Metabolism*
Neuropeptides / pharmacology*
Periplaneta / drug effects*,  metabolism*
Phospholipases / metabolism
Phospholipids / metabolism
Quinacrine / pharmacology
Reg. No./Substance:
0/Neuropeptides; 0/Phospholipids; 83-89-6/Quinacrine; 93208-51-6/glutamyl-valyl-asparaginyl-phenylalanyl-seryl-prolyl-asparaginyl-tryptophanamide; EC 3.1.-/Phospholipases

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