Document Detail

Lipid metabolism in cachectic tumor-bearing rats at different stages of tumor growth.
MedLine Citation:
PMID:  8446517     Owner:  NLM     Status:  MEDLINE    
Rates of lipogenesis and lipoprotein lipase (LPL) activity were measured in liver, adipose tissue, heart, and tumor at several stages during 10 days of palpable growth of a transplantable Leydig cell tumor in rats. This model showed the same characteristics as human cancer cachexia, including anorexia, weight loss, and muscle wasting. Comparison with pair-fed controls showed that the rate of loss of body fat was greater than could be explained by anorexia alone. The rate of lipogenesis tended to decrease during the later stages of tumor growth, particularly in the liver, where there was a statistically significant reduction on Days 5 and 10. This may be largely attributable to decreased availability of substrates caused by decreasing food intake and increasing glucose uptake by the tumor. There was a significant decrease in plasma glucose concentration by Day 10. In contrast, LPL activity in adipose tissue was depressed from the earliest stage of tumor growth, and this is likely to be a major cause of lipid depletion in cancer. There was no difference in adipose tissue LPL activity between the fed and postabsorptive states in the tumor-bearing rats, indicating that the normal response to nutrient intake was impaired. Thus, treatment of cancer cachexia should concentrate on normalizing the metabolic response to nutrient ingestion.
O A Obeid; P W Emery
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition and cancer     Volume:  19     ISSN:  0163-5581     ISO Abbreviation:  Nutr Cancer     Publication Date:  1993  
Date Detail:
Created Date:  1993-04-06     Completed Date:  1993-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-98     Citation Subset:  IM    
Department of Nutrition and Dietetics, King's College, London, UK.
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MeSH Terms
Blood Glucose / analysis
Body Weight
Cachexia / blood,  enzymology,  etiology,  metabolism*
Disease Models, Animal
Leydig Cell Tumor / blood,  enzymology,  metabolism*
Lipid Metabolism*
Lipoprotein Lipase / metabolism*
Rats, Inbred F344
Tumor Cells, Cultured
Reg. No./Substance:
0/Blood Glucose; EC Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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