Document Detail


Lipid metabolism in the adipose tissues of a carnivore, the raccoon dog, during prolonged fasting.
MedLine Citation:
PMID:  17202586     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies on laboratory rodents, rabbits, and humans have demonstrated that adipose tissue fatty acid (FA) mobilization is selective, and its efficiency is related to the molecular structure of FAs. This study was undertaken to find out whether such preferences of FA mobilization are a general feature of mammalian white adipose tissue (WAT) and are also manifested in carnivores. Fractional mobilization of a wide spectrum of FAs was studied by gas-liquid chromatography from six subcutaneous (scapular, rump, ventral) and intra-abdominal (omental, mesenteric, retroperitoneal) WAT depots of raccoon dogs (Nyctereutes procyonoides) fed or fasted for 2 months. Fasting stimulated the mobilization of shorter-chain saturated, mono-unsaturated (MUFAs), and polyunsaturated FAs (PUFAs). The effects of unsaturation and the position of the first double bond from the methyl end were more inconsistent. The effect of double-bond position may be due to chain shortening of longer-chain MUFAs and preferential utilization of n-3 PUFAs over n-6 PUFAs. Moreover, there were site-specific differences in fractional mobilization, the omental adipose tissue being the most divergent. The in vivo FA mobilization from the regional WAT depots of a carnivore was selective, and the molecular structure of the FA affected its efficiency.
Authors:
Anne-Mari Mustonen; Reijo Käkelä; Anne Käkelä; Teija Pyykönen; Jari Aho; Petteri Nieminen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  232     ISSN:  1535-3702     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-04     Completed Date:  2007-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  58-69     Citation Subset:  IM    
Affiliation:
Faculty of Biosciences, University of Joensuu, FIN-80101, Joensuu, Finland. ammusto@cc.joensuu.fi
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MeSH Terms
Descriptor/Qualifier:
Animals
Fasting / metabolism*
Fatty Acids / chemistry,  metabolism
Gas Chromatography-Mass Spectrometry
Intra-Abdominal Fat / metabolism*
Lipid Mobilization*
Raccoon Dogs / metabolism*
Subcutaneous Fat / metabolism*
Chemical
Reg. No./Substance:
0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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