Document Detail

Lipid metabolism during lactation: a review of adipose tissue-liver interactions and the development of fatty liver.
MedLine Citation:
PMID:  16223462     Owner:  NLM     Status:  MEDLINE    
Fatty acids are the major source of energy for most tissues during periods of negative energy balance; however, fatty acids can, in some circumstances, have pathological effects. Fatty acids are stored as triacylglycerols (TAG), mostly in the various adipose tissue depots of the body. However, if blood unesterified fatty acid (NEFA) levels are elevated for prolonged periods, as may occur during lactation or obesity, TAG can accumulate in other tissues including liver and muscle cells (myocytes), and this can have pathological consequences such as the development of ketosis (Grummer, 1993; Drackley et al. 2001) or type 2 diabetes (Boden & Shulman, 2002; McGarry, 2002).
Richard G Vernon
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of dairy research     Volume:  72     ISSN:  0022-0299     ISO Abbreviation:  J. Dairy Res.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-14     Completed Date:  2006-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985125R     Medline TA:  J Dairy Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  460-9     Citation Subset:  IM    
Hannah Research Institute, Ayr, KA6 5HL, UK.
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MeSH Terms
Adipose Tissue / metabolism,  secretion
Cattle / metabolism,  physiology*
Cattle Diseases / metabolism*
Fatty Acids / metabolism
Fatty Liver / etiology,  metabolism*
Lactation / metabolism*
Lipid Metabolism*
Liver / metabolism
Reg. No./Substance:
0/Fatty Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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