| Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease. | |
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MedLine Citation:
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PMID: 21403820 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Parkinson's disease (PD) is a neurodegenerative movement disorder of unknown etiology. PD is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, depletion of dopamine in the striatum, abnormal mitochondrial and proteasomal functions, and accumulation of α-synuclein that may be closely associated with pathological and clinical abnormalities. Increasing evidence indicates that both oxidative stress and inflammation may play a fundamental role in the pathogenesis of PD. Oxidative stress is characterized by increase in reactive oxygen species (ROS) and depletion of glutathione. Lipid mediators for oxidative stress include 4-hydroxynonenal, isoprostanes, isofurans, isoketals, neuroprostanes, and neurofurans. Neuroinflammation is characterized by activated microglial cells that generate proinflammatory cytokines, such as TNF-α and IL-1β. Proinflammatory lipid mediators include prostaglandins and platelet activating factor, together with cytokines may play a prominent role in mediating the progressive neurodegeneration in PD. |
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Authors:
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Tahira Farooqui; Akhlaq A Farooqui |
Publication Detail:
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Type: Journal Article Date: 2011-02-15 |
Journal Detail:
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Title: Parkinson's disease Volume: 2011 ISSN: 2042-0080 ISO Abbreviation: Parkinsons Dis Publication Date: 2011 |
Date Detail:
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Created Date: 2011-03-15 Completed Date: 2011-07-14 Revised Date: 2011-07-26 |
Medline Journal Info:
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Nlm Unique ID: 101539877 Medline TA: Parkinsons Dis Country: England |
Other Details:
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Languages: eng Pagination: 247467 Citation Subset: - |
Affiliation:
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Department of Entomology/Center for Molecular Neurobiology, The Ohio State University, Columbus, OH 43210, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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