Document Detail


Lipid lowering therapy leads to a reduction in sodium-lithium countertransport activity.
MedLine Citation:
PMID:  1854357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythrocyte sodium-lithium countertransport (SLC) was measured in 17 patients with either combined hyperlipidaemia or hypercholesterolaemia before and after lipid lowering therapy. Before treatment SLC related to the serum triglyceride level and was increased in combined hyperlipidaemia. After treatment the SLC had returned to normal and the change in SLC was related to the change in serum triglyceride levels. Raised SLC is associated with essential hypertension but is not related to blood pressure. Therefore, the association of raised SLC with hyperlipidaemia and essential hypertension appears to have different underlying mechanisms.
Authors:
S J Carr; T H Thomas; M F Laker; R Wilkinson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  87     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-08-16     Completed Date:  1991-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  103-8     Citation Subset:  IM    
Affiliation:
Department of Medicine and Nephrology, Freeman Hospital, Newcastle upon Tyne, U.K.
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Transport, Active
Cholesterol / blood
Erythrocytes / metabolism
Female
Humans
Hyperlipidemias / blood,  therapy*
Lipids / blood*
Lithium / blood*
Male
Middle Aged
Sodium / blood*
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Lipids; 0/Triglycerides; 57-88-5/Cholesterol; 7439-93-2/Lithium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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