| Lipid-lowering effects of ezetimibe for hypercholesterolemic patients with and without type 2 diabetes mellitus. | |
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MedLine Citation:
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PMID: 20733267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To date, there are very few clinical reports that have compared the effects of ezetimibe on lipid parameters between hypercholesterolemic patients with and without type 2 diabetes mellitus (T2DM). In this study, we recruited patients for hypercholesterolemic groups with T2DM (n = 42; men/women = 24/18; HbA1c = 6.7 ± 5.4%) and without T2DM (n = 21; men/women = 7/14; HbA1c = 5.3 ± 0.4%). Patients were prescribed ezetimibe at a dose of 10 mg/daily for the course of the 12-week study. At baseline and after 12 weeks of treatment, several lipid parameters, including serum low-density-lipoprotein cholesterol (LDL-C), non-high-density-lipoprotein cholesterol (non-HDL-C), high-sensitivity C-reactive protein (hs-CRP), and cholesterol synthesis/absorption-related markers, were measured. Compared with those at the baseline, the levels of LDL-C, non-HDL-C, campesterol, and sitosterol were significantly reduced after 12 weeks of ezetimibe treatment in both groups. After adjusting for confounding factors, such as age, gender, smoking, and BMI, the levels of LDL-C and non-HDL-C displayed significantly greater reductions in the patients with T2DM (-25.1 ± 13.6% in LDL-C, -20.5 ± 11.2% in non-HDL-C) than those without T2DM (-20.5 ± 7.8% in LDL-C, P < 0.05; -17.4 ± 7.6% in non-HDL-C, P < 0.05). The reduction of the level of cholestanol was significantly and positively correlated with those of LDL-C and non-HDL-C in the patients with T2DM. Taken together, these findings indicate that ezetimibe could reduce the levels of atherogenic lipoproteins to a greater extent in hypercholesterolemic patients with T2DM than in those without T2DM. |
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Authors:
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Kenta Okada; Hiroaki Yagyu; Kazuhiko Kotani; Michiaki Miyamoto; Jun-ichi Osuga; Shoichiro Nagasaka; Shun Ishibashi |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article Date: 2010-08-20 |
Journal Detail:
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Title: Endocrine journal Volume: 57 ISSN: 1348-4540 ISO Abbreviation: Endocr. J. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-04 Completed Date: 2011-03-03 Revised Date: 2011-06-16 |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 903-8 Citation Subset: IM |
Affiliation:
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Utsunomiya Social Insurance Hospital, Tochigi, Japan. kokada@jichi.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Azetidines / therapeutic use* Biological Markers / blood Body Mass Index C-Reactive Protein / analysis Cardiovascular Diseases / prevention & control Cholestanol / blood Cholesterol / analogs & derivatives, blood, metabolism Cholesterol, LDL / blood Diabetes Mellitus, Type 2 / complications*, drug therapy Female Humans Hypercholesterolemia / blood, complications*, drug therapy* Hypolipidemic Agents / therapeutic use* Lipids / blood* Male Middle Aged Phytosterols / blood Sitosterols / blood |
| Chemical | |
Reg. No./Substance:
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0/Azetidines; 0/Biological Markers; 0/Cholesterol, LDL; 0/Hypolipidemic Agents; 0/Lipids; 0/Phytosterols; 0/Sitosterols; 163222-33-1/ezetimibe; 474-62-4/campesterol; 57-88-5/Cholesterol; 5779-62-4/sitosterol; 80-97-7/Cholestanol; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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