| Lipid levels after acute coronary syndromes. | |
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MedLine Citation:
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PMID: 18402897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: This analysis from the LUNAR (Limiting UNdertreatment of lipids in ACS with Rosuvastatin) study assessed lipid changes 1 to 4 days after onset of acute coronary syndromes (ACS), before initiation of study treatment. BACKGROUND: Early studies indicated that cholesterol levels decrease significantly after ACS. However, most studies were small or did not measure low-density lipoprotein cholesterol (LDL-C) directly, and many used nonfasting or retrospective data. More recent studies suggest less pronounced changes in cholesterol levels after ACS. METHODS: The LUNAR trial is a prospective, multicenter, randomized, open-label study in adults hospitalized for acute ST-segment elevation myocardial infarction (STEMI), non-STEMI, or unstable angina (UA). Blood samples were taken at median times after onset of ACS symptoms of 26 h (Day 1, fasting or nonfasting sample), 43 h (Day 2, fasting sample), and 84 h (Day 4, fasting sample) for direct measurement of serum lipid levels before study treatments were started. RESULTS: Of 507 patients available for analysis, 212 were admitted for STEMI, 176 for non-STEMI, and 119 for UA. The LDL-C levels decreased in the 24 h after admission (from 136.2 to 133.5 mg/dl), followed by an increase over the subsequent 2 days (to 141.8 mg/dl). These changes did not seem to be clinically meaningful. Similar changes were observed for total cholesterol and smaller changes for high-density lipoprotein cholesterol; fasting triglyceride levels did not change. CONCLUSIONS: Mean lipid levels vary relatively little in the 4 days after an ACS and can be used to guide selection of lipid-lowering medication. |
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Authors:
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Bertram Pitt; Joseph Loscalzo; Joseph Ycas; Joel S Raichlen |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 51 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-11 Completed Date: 2008-05-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1440-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA. bpitt@med.umich.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00214630 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
/
blood*,
drug therapy,
physiopathology Adolescent Adult Aged Angina, Unstable / blood Anticholesteremic Agents / therapeutic use Cholesterol, LDL / drug effects* Female Fluorobenzenes / therapeutic use Heart Conduction System / physiopathology* Heptanoic Acids / therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use Male Middle Aged Myocardial Infarction / blood Prognosis Prospective Studies Pyrimidines / therapeutic use Pyrroles / therapeutic use Randomized Controlled Trials as Topic Sulfonamides / therapeutic use Time Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, LDL; 0/Fluorobenzenes; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Pyrroles; 0/Sulfonamides; 0/Triglycerides; 110862-48-1/atorvastatin; 287714-41-4/rosuvastatin |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2008 Apr 15;51(15):1446-7
[PMID:
18402898
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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