Document Detail

Lipid and inflammatory markers for the prediction of coronary artery disease: a multi-marker approach.
MedLine Citation:
PMID:  17632095     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Many studies have investigated the clinical accuracy of single lipid and inflammatory markers. In contrast, few have evaluated their potential for the detection of CAD using a multi-marker approach. METHODS: The concentrations of lipid, lipoproteins, apolipoproteins, high sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured by standard laboratory methods. Apolipoprotein (a) [apo(a)] phenotyping was performed by sodium dodecylsulphate-gel electrophoresis and immunoblotting. The lipid tetrad index (LTI) and the lipid pentad index (LPI) were calculated. Clinical accuracy of the examined parameters, indexes and a logistic regression model was assessed using receiving operative characteristic (ROC) curve analysis. RESULTS: Logistic regression analysis indicated that non-HDL-c, hs-CRP, HDL-c and Lp(a) were significant independent predictors for CAD. The AUC for this model (0.802) was higher than AUCs for any single marker or index tested. CONCLUSIONS: We conclude that the performance of a logistic regression model for CAD prediction warrants its use in clinical practice.
Natasa Bogavac-Stanojević; Zorana Jelić-Ivanović; Vesna Spasojević-Kalimanovska; Slavica Spasić; Dimitra Kalimanovska-Ostrić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-08
Journal Detail:
Title:  Clinical biochemistry     Volume:  40     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-28     Completed Date:  2007-11-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1000-6     Citation Subset:  IM    
Institute of Medical Biochemistry, Faculty of Pharmacy, POB 146, 11000 Belgrade, Serbia.
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MeSH Terms
Apolipoproteins / blood
Biological Markers / blood*
C-Reactive Protein / metabolism
Confidence Intervals
Coronary Artery Disease / blood*,  diagnosis
Fibrinogen / metabolism
Inflammation / blood
Lipids / blood*
Lipoprotein(a) / blood
Middle Aged
Predictive Value of Tests
ROC Curve
Risk Factors
Reg. No./Substance:
0/Apolipoproteins; 0/Biological Markers; 0/Lipids; 0/Lipoprotein(a); 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

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