Document Detail


Lipid and fatty acid composition of brush border membrane of rat intestine during starvation.
MedLine Citation:
PMID:  9870904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Alterations in the lipid and fatty acid composition of brush border membrane (BBM) of small intestine were studied in well-fed, starved, and refed rats. The ratios of cholesterol/phospholipid (mol/mol), sphingomyelin/phosphatidylcholine (mol/mol), protein/lipid (w/w), and free fatty acids (w/w) decreased whereas the total phospholipid (w/w) ratio and the double-bond index increased in BBM of the intestine of the starved rat compared to that of the well-fed rat. Analyses of fatty acids showed higher percentage of stearic and arachidonic acids whereas oleic and linoleic acids decreased under starvation. The acyl chain of starved rat BBM was less ordered compared with that of well-fed rat BBM. On refeeding, these changes were restored to well-fed levels. The change in membrane state under starvation is associated with alterations in the lipid and fatty acid composition of BBM and may be responsible for functional changes that occur under nutritional stress.
Authors:
A A Waheed; F Yasuzumi; P D Gupta
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  33     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-03-18     Completed Date:  1999-03-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1093-7     Citation Subset:  IM    
Affiliation:
Centre for Cellular and Molecular Biology, Hyderabad, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholesterol / analysis
Fatty Acids / analysis*
Fatty Acids, Nonesterified / analysis
Fatty Acids, Unsaturated / analysis
Intestinal Mucosa / chemistry*
Male
Membrane Lipids / chemistry*
Microvilli / chemistry*
Phospholipids / analysis
Rats
Rats, Wistar
Starvation*
Stress, Physiological
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Unsaturated; 0/Membrane Lipids; 0/Phospholipids; 57-88-5/Cholesterol

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