Document Detail

Lipid entrapment and cellular changes in the rat myocard, lung and liver after long-term parenteral nutrition with lipid emulsion. A light microscopic and ultrastructural study.
MedLine Citation:
PMID:  8920804     Owner:  NLM     Status:  MEDLINE    
We have demonstrated organ damage after long-term administration of lipid-based parenteral nutrition, possibly initiated by intravascular pooling of lipid and phagocytes, in both rats and pigs. To evaluate whether accumulation of lipid could simply be caused by mechanical filtration, a comparative study of three separate capillary beds was performed. Rats were given lipid emulsion (n = 5) or isotonic saline (n = 4) through central venous catheters for 3 weeks. Using both light and electron microscopy, lipid accumulation and structural changes in the rat myocard were compared to those in the lung and liver. The study provides evidence that within myocardial capillaries both peripheral blood monocytes and endothelial cells performed phagocytosis of lipid droplets following administration of lipid emulsion, but no large-scale intravascular pooling of lipid resulted. Morphometry of the myocard detected no lipid increase in the myocytes from the rats given lipid emulsion compared with controls and in neither were there any stigmata of vasculitis or myocardial damage, in contrast to the lung and liver, where intravascular pooling of lipid and phagocytes was seen. This indicates that phagocytosis was an important mechanism involved in entrapment and elimination of lipid.
J Aksnes; T J Eide; K Nordstrand
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  104     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1996-12-24     Completed Date:  1996-12-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  515-22     Citation Subset:  IM    
Cardiothoracic Unit, National Hospital, University of Oslo, Norway.
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MeSH Terms
Capillaries / metabolism
Endothelium, Vascular / metabolism
Lipid Metabolism*
Liver / metabolism*
Lung / metabolism*
Macrophages / metabolism
Myocardium / metabolism*
Parenteral Nutrition / adverse effects*
Rats, Wistar
Reg. No./Substance:

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