| Lipid droplets as fat storage organelles in Caenorhabditis elegans. | |
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MedLine Citation:
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PMID: 22049244 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lipid droplets are evolutionarily conserved organelles where cellular fat storage andmobilization are exquisitely regulated. Recent studies have defined lipid droplets in C. elegansand explored how they are regulated by genetic and dietary factors. C. elegans offers uniqueopportunities to visualize lipid droplets at single cell resolution in live animals. Thedevelopment of novel microscopy techniques and protein markers for lipid droplets willaccelerate studies on how nutritional states and subcellular organization are linked in vivo.Together with powerful tools for genetic and biochemical analysis of metabolic pathways,alteration in lipid droplet abundance, size and distribution in C. elegans can be readily connectedto whole animal energy homeostasis, behavior and life span. Therefore, further studies on lipiddroplets in C. elegans promise to yield valuable insights that complement our knowledge gainedfrom yeast, Drosophila and mammalian systems on cellular and organismal fat storage. |
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Authors:
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Ho Yi Mak |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-2 |
Journal Detail:
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Title: Journal of lipid research Volume: - ISSN: 0022-2275 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Stowers Institute for Medical Research, United States. |
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