Document Detail

Lipid digestion and absorption in early life: an update.
MedLine Citation:
PMID:  20179589     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To highlight our understanding of digestion and absorption of dietary lipids in newborn infants, and specifically how these processes differ from those in children and adults. RECENT FINDINGS: The intestinal concentration of pancreatic triglyceride lipase (PTL) and bile salts is lower in newborns compared to later in life. Instead the PTL-related protein 2 and bile salt-stimulated lipase (BSSL) are the key enzymes secreted from pancreas, which in concerted action with gastric lipase operate to achieve efficient fat absorption during infancy. BSSL is also present in human milk which affects fat absorption and growth in breast-fed preterm infants. Under conditions of low luminal bile salt concentrations fat absorption is likely to occur from liquid crystalline product phases, which may result in absorption from an extended part of the small intestinal mucosal surfaces compared to adults. Chylomicron assembly and secretion also seem to adapt to the specific situation of the newborn. SUMMARY: Both fat digestion and product absorption are different in newborn infants compared to adults; other lipases are used for digestion and different physical-chemical phases may be used for product absorption. Why these differences occur is still an unsolved question of considerable importance to neonatal nutrition.
Susanne Lindquist; Olle Hernell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  13     ISSN:  1535-3885     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-15     Completed Date:  2010-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  314-20     Citation Subset:  IM    
Department of Clinical Sciences/Pediatrics, Umeå University, Umeå, Sweden.
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MeSH Terms
Bile Acids and Salts / metabolism*
Breast Feeding
Chylomicrons / metabolism
Dietary Fats / metabolism*
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Infant, Premature
Intestinal Absorption
Intestinal Mucosa / metabolism
Intestine, Small / metabolism*
Lipase / metabolism*
Lipid Metabolism*
Milk, Human / chemistry
Pancreas / enzymology
Reg. No./Substance:
0/Bile Acids and Salts; 0/Chylomicrons; 0/Dietary Fats; EC protein, human; EC

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