Document Detail


Lipid digestion and absorption in early life: an update.
MedLine Citation:
PMID:  20179589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: To highlight our understanding of digestion and absorption of dietary lipids in newborn infants, and specifically how these processes differ from those in children and adults. RECENT FINDINGS: The intestinal concentration of pancreatic triglyceride lipase (PTL) and bile salts is lower in newborns compared to later in life. Instead the PTL-related protein 2 and bile salt-stimulated lipase (BSSL) are the key enzymes secreted from pancreas, which in concerted action with gastric lipase operate to achieve efficient fat absorption during infancy. BSSL is also present in human milk which affects fat absorption and growth in breast-fed preterm infants. Under conditions of low luminal bile salt concentrations fat absorption is likely to occur from liquid crystalline product phases, which may result in absorption from an extended part of the small intestinal mucosal surfaces compared to adults. Chylomicron assembly and secretion also seem to adapt to the specific situation of the newborn. SUMMARY: Both fat digestion and product absorption are different in newborn infants compared to adults; other lipases are used for digestion and different physical-chemical phases may be used for product absorption. Why these differences occur is still an unsolved question of considerable importance to neonatal nutrition.
Authors:
Susanne Lindquist; Olle Hernell
Related Documents :
16988079 - A physiological role of breast milk leptin in body weight control in developing infants.
16699799 - Transfer of reboxetine into breastmilk, its plasma concentrations and lack of adverse e...
973609 - Perinatal methylmercury poisoning in iraq.
3946289 - Cu nutrition in infants during prolonged exclusive breast-feeding: low intake but risin...
7293949 - Evaluation of lactational performance of navajo women.
2690739 - Early diet in preterm babies and developmental status in infancy.
16988079 - A physiological role of breast milk leptin in body weight control in developing infants.
22609019 - Prevalence of iron deficiency at the first age of the infants hospitalized in neonatal ...
17620629 - An update on anemia in less developed countries.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  13     ISSN:  1535-3885     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-15     Completed Date:  2010-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  314-20     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences/Pediatrics, Umeå University, Umeå, Sweden. susanne.lindquist@pediatri.umu.se
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Bile Acids and Salts / metabolism*
Breast Feeding
Chylomicrons / metabolism
Dietary Fats / metabolism*
Digestion*
Humans
Infant Nutritional Physiological Phenomena*
Infant, Newborn
Infant, Premature
Intestinal Absorption
Intestinal Mucosa / metabolism
Intestine, Small / metabolism*
Lipase / metabolism*
Lipid Metabolism*
Milk, Human / chemistry
Pancreas / enzymology
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Chylomicrons; 0/Dietary Fats; EC 3.1.1.3/CEL protein, human; EC 3.1.1.3/Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Early growth patterns and long-term obesity risk.
Next Document:  Coupling microcirculation to systemic hemodynamics.