Document Detail

Lipid content and time-to-death-dependent lethal body burdens of naphthalene and 1,2,4-trichlorobenzene in fathead minnow (Pimephales promelas).
MedLine Citation:
PMID:  9469874     Owner:  NLM     Status:  MEDLINE    
For naphthalene (NAPH) and 1,2,4-trichlorobenzene (TCBz), lethal body burdens (LBB) of 8 +/- 3.1 mmol/kg wet wt (ww) and 14 +/- 4.5 mmol/kg (ww), respectively, were determined in fathead minnow (Pimephales promelas). LBBs of both compounds were found to increase with increasing lipid content and time-to-death of fish within the same aquarium. The correlation with time-to-death suggests that besides lipid content at least one other factor causes intraspecies variation in LBBs. When intraspecies variation is excluded by comparing mean LBBs from different aquaria and exposure regimes, LBBs still vary with time-to-death. In contrast to the situation within one aquarium, between different aquaria and exposure regimes often a decrease in LBB with time-to-death is found. The present study and others indicate that LBBs can vary with time-to-death. Therefore, a time-independent LBB cannot be assumed.
P G de Maagd; I C van de Klundert; A P van Wezel; A Opperhuizen; D T Sijm
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  38     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-05-19     Completed Date:  1998-05-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  232-7     Citation Subset:  IM    
RITOX/Environmental Chemistry Group, Utrecht University, The Netherlands.
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MeSH Terms
Body Burden
Chlorobenzenes / analysis*,  toxicity
Cyprinidae / metabolism*
Lipids / analysis
Naphthalenes / analysis*,  toxicity
Structure-Activity Relationship
Time Factors
Water Pollutants, Chemical / analysis*,  toxicity
Reg. No./Substance:
0/Chlorobenzenes; 0/Lipids; 0/Naphthalenes; 0/Water Pollutants, Chemical; 120-82-1/1,2,4-trichlorobenzene; 91-20-3/naphthalene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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